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Erythropoietin-stimulating agent-resistant vitamin B 6 deficiency anemia in a pediatric patient on hemodialysis
Vitamin B is a rate-limiting coenzyme that plays an important role in the biosynthesis of heme and the incorporation of iron into protoporphyrin. Its deficiency is often seen in chronic kidney disease (CKD), particularly those requiring dialysis and following administration of erythropoietin-stimula...
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| Published in: | Pediatric nephrology (Berlin, West) West), 2021-02, Vol.36 (2), p.473 |
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| Language: | English |
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| container_issue | 2 |
| container_start_page | 473 |
| container_title | Pediatric nephrology (Berlin, West) |
| container_volume | 36 |
| creator | Searcy, Kristie Rainwater, Sarah Jeroudi, Majed Baliga, Radhakrishna |
| description | Vitamin B
is a rate-limiting coenzyme that plays an important role in the biosynthesis of heme and the incorporation of iron into protoporphyrin. Its deficiency is often seen in chronic kidney disease (CKD), particularly those requiring dialysis and following administration of erythropoietin-stimulating agent (ESA).
A 16-year-old African-American male with stage 5 CKD on chronic hemodialysis experienced a decrease in hemoglobin over a 3-month period from 11 to 6.5 g/dl while receiving ESA, resulting in multiple blood transfusions. His transferrin saturation was 41%, ferritin level 706 [80-388] ng/mL, mean corpuscular volume (MCV) 87 [78-98] μm
, corrected reticulocytes count 2.3% [0.2-1.8%], and vitamin B
1.2 [5.3-46.7] μg/L. Bone marrow biopsy was normocellular (65%) with erythroid hyperplasia and rare dyserythropoiesis. Prussian blue staining showed increased iron storage. Supplemental vitamin B
(100 mg daily) was initiated at hemoglobin 7.3 g/dL with correction of anemia. Eighteen months later, his hemoglobin is 11.7 g/dL, transferrin saturation 45%, with no additional blood transfusions.
Vitamin B
deficiency anemia should be considered in any pediatric patient on hemodialysis who does not respond to standard ESA and iron therapy. |
| doi_str_mv | 10.1007/s00467-020-04810-1 |
| format | article |
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is a rate-limiting coenzyme that plays an important role in the biosynthesis of heme and the incorporation of iron into protoporphyrin. Its deficiency is often seen in chronic kidney disease (CKD), particularly those requiring dialysis and following administration of erythropoietin-stimulating agent (ESA).
A 16-year-old African-American male with stage 5 CKD on chronic hemodialysis experienced a decrease in hemoglobin over a 3-month period from 11 to 6.5 g/dl while receiving ESA, resulting in multiple blood transfusions. His transferrin saturation was 41%, ferritin level 706 [80-388] ng/mL, mean corpuscular volume (MCV) 87 [78-98] μm
, corrected reticulocytes count 2.3% [0.2-1.8%], and vitamin B
1.2 [5.3-46.7] μg/L. Bone marrow biopsy was normocellular (65%) with erythroid hyperplasia and rare dyserythropoiesis. Prussian blue staining showed increased iron storage. Supplemental vitamin B
(100 mg daily) was initiated at hemoglobin 7.3 g/dL with correction of anemia. Eighteen months later, his hemoglobin is 11.7 g/dL, transferrin saturation 45%, with no additional blood transfusions.
Vitamin B
deficiency anemia should be considered in any pediatric patient on hemodialysis who does not respond to standard ESA and iron therapy.</description><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s00467-020-04810-1</identifier><identifier>PMID: 33156411</identifier><language>eng</language><publisher>Germany</publisher><subject>Adolescent ; Anemia - drug therapy ; Anemia - etiology ; Anemia, Iron-Deficiency ; Child ; Epoetin Alfa ; Erythropoietin ; Hematinics - therapeutic use ; Hemoglobins - metabolism ; Humans ; Iron ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - therapy ; Male ; Renal Dialysis - adverse effects ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - therapy ; Transferrins ; Vitamin B 6 ; Vitamins</subject><ispartof>Pediatric nephrology (Berlin, West), 2021-02, Vol.36 (2), p.473</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-3978-3060</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33156411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Searcy, Kristie</creatorcontrib><creatorcontrib>Rainwater, Sarah</creatorcontrib><creatorcontrib>Jeroudi, Majed</creatorcontrib><creatorcontrib>Baliga, Radhakrishna</creatorcontrib><title>Erythropoietin-stimulating agent-resistant vitamin B 6 deficiency anemia in a pediatric patient on hemodialysis</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><description>Vitamin B
is a rate-limiting coenzyme that plays an important role in the biosynthesis of heme and the incorporation of iron into protoporphyrin. Its deficiency is often seen in chronic kidney disease (CKD), particularly those requiring dialysis and following administration of erythropoietin-stimulating agent (ESA).
A 16-year-old African-American male with stage 5 CKD on chronic hemodialysis experienced a decrease in hemoglobin over a 3-month period from 11 to 6.5 g/dl while receiving ESA, resulting in multiple blood transfusions. His transferrin saturation was 41%, ferritin level 706 [80-388] ng/mL, mean corpuscular volume (MCV) 87 [78-98] μm
, corrected reticulocytes count 2.3% [0.2-1.8%], and vitamin B
1.2 [5.3-46.7] μg/L. Bone marrow biopsy was normocellular (65%) with erythroid hyperplasia and rare dyserythropoiesis. Prussian blue staining showed increased iron storage. Supplemental vitamin B
(100 mg daily) was initiated at hemoglobin 7.3 g/dL with correction of anemia. Eighteen months later, his hemoglobin is 11.7 g/dL, transferrin saturation 45%, with no additional blood transfusions.
Vitamin B
deficiency anemia should be considered in any pediatric patient on hemodialysis who does not respond to standard ESA and iron therapy.</description><subject>Adolescent</subject><subject>Anemia - drug therapy</subject><subject>Anemia - etiology</subject><subject>Anemia, Iron-Deficiency</subject><subject>Child</subject><subject>Epoetin Alfa</subject><subject>Erythropoietin</subject><subject>Hematinics - therapeutic use</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Iron</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Renal Dialysis - adverse effects</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - therapy</subject><subject>Transferrins</subject><subject>Vitamin B 6</subject><subject>Vitamins</subject><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNo1j89KAzEYxIMgtlZfwIPkBaJfNtls9qil_oGCFwVv5dtN0ka62bBJhX17A-pphhnmB0PIDYc7DtDcJwCpGgYVMJCaA-NnZMmlqBhv9eeCXKb0BQC61uqCLITgtZKcL8m4meZ8mMY4ept9YCn74XTEYvcU9zZkNtnkU8aQ6bfPOPhAH6mixjrfexv6mWKwg0daCqTRGo958j2NhVHmdAz0YIexxMe5gK7IucNjstd_uiIfT5v39Qvbvj2_rh-2LHLQmXUWpHHQtYa7xiiDleylE1KDcY6j4doK6NtOqKYEStct1KiUaTqolDRarMjtLzeeusGaXZz8gNO8-38ufgBk31xy</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Searcy, Kristie</creator><creator>Rainwater, Sarah</creator><creator>Jeroudi, Majed</creator><creator>Baliga, Radhakrishna</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0002-3978-3060</orcidid></search><sort><creationdate>202102</creationdate><title>Erythropoietin-stimulating agent-resistant vitamin B 6 deficiency anemia in a pediatric patient on hemodialysis</title><author>Searcy, Kristie ; Rainwater, Sarah ; Jeroudi, Majed ; Baliga, Radhakrishna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p108t-be04df0b9d1f7d6da24c4f3480dff1ad18e30c9b367dff685905a66d7b0264d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Anemia - drug therapy</topic><topic>Anemia - etiology</topic><topic>Anemia, Iron-Deficiency</topic><topic>Child</topic><topic>Epoetin Alfa</topic><topic>Erythropoietin</topic><topic>Hematinics - therapeutic use</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Iron</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Renal Dialysis - adverse effects</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - therapy</topic><topic>Transferrins</topic><topic>Vitamin B 6</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Searcy, Kristie</creatorcontrib><creatorcontrib>Rainwater, Sarah</creatorcontrib><creatorcontrib>Jeroudi, Majed</creatorcontrib><creatorcontrib>Baliga, Radhakrishna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Searcy, Kristie</au><au>Rainwater, Sarah</au><au>Jeroudi, Majed</au><au>Baliga, Radhakrishna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Erythropoietin-stimulating agent-resistant vitamin B 6 deficiency anemia in a pediatric patient on hemodialysis</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><addtitle>Pediatr Nephrol</addtitle><date>2021-02</date><risdate>2021</risdate><volume>36</volume><issue>2</issue><spage>473</spage><pages>473-</pages><eissn>1432-198X</eissn><abstract>Vitamin B
is a rate-limiting coenzyme that plays an important role in the biosynthesis of heme and the incorporation of iron into protoporphyrin. Its deficiency is often seen in chronic kidney disease (CKD), particularly those requiring dialysis and following administration of erythropoietin-stimulating agent (ESA).
A 16-year-old African-American male with stage 5 CKD on chronic hemodialysis experienced a decrease in hemoglobin over a 3-month period from 11 to 6.5 g/dl while receiving ESA, resulting in multiple blood transfusions. His transferrin saturation was 41%, ferritin level 706 [80-388] ng/mL, mean corpuscular volume (MCV) 87 [78-98] μm
, corrected reticulocytes count 2.3% [0.2-1.8%], and vitamin B
1.2 [5.3-46.7] μg/L. Bone marrow biopsy was normocellular (65%) with erythroid hyperplasia and rare dyserythropoiesis. Prussian blue staining showed increased iron storage. Supplemental vitamin B
(100 mg daily) was initiated at hemoglobin 7.3 g/dL with correction of anemia. Eighteen months later, his hemoglobin is 11.7 g/dL, transferrin saturation 45%, with no additional blood transfusions.
Vitamin B
deficiency anemia should be considered in any pediatric patient on hemodialysis who does not respond to standard ESA and iron therapy.</abstract><cop>Germany</cop><pmid>33156411</pmid><doi>10.1007/s00467-020-04810-1</doi><orcidid>https://orcid.org/0000-0002-3978-3060</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1432-198X |
| ispartof | Pediatric nephrology (Berlin, West), 2021-02, Vol.36 (2), p.473 |
| issn | 1432-198X |
| language | eng |
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| source | Springer Link |
| subjects | Adolescent Anemia - drug therapy Anemia - etiology Anemia, Iron-Deficiency Child Epoetin Alfa Erythropoietin Hematinics - therapeutic use Hemoglobins - metabolism Humans Iron Kidney Failure, Chronic - complications Kidney Failure, Chronic - therapy Male Renal Dialysis - adverse effects Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - therapy Transferrins Vitamin B 6 Vitamins |
| title | Erythropoietin-stimulating agent-resistant vitamin B 6 deficiency anemia in a pediatric patient on hemodialysis |
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