Interference of altered plasma trace elements profile with hyperhomocysteinemia and oxidative stress damage to insulin secretion dysfunction in Psammomys obesus: focus on the selenium

The objective of this study is to investigate the relationship between altered plasma trace elements, particularly selenium (Se), with Hyper-homocysteinemia (HhCys) as a predictive factor of insulin secretion dysfunction. The study is carried out on adult Psammomys obesus, divided in 4 experimental...

Full description

Saved in:
Bibliographic Details
Published in:Archives of physiology and biochemistry 2023-03, Vol.129 (2), p.505-518
Main Authors: Bouazza, Asma, Fontaine, Eric, Leverve, Xavier, Koceir, Elhadj-Ahmed
Format: Article
Language:English
Subjects:
Animals
Diabetes Mellitus, Type 2 - metabolism
Gerbillinae - metabolism
Hyperglycemia - metabolism
hyperhomocysteine
Hyperhomocysteinemia
Insulin
Insulin Secretion
Life Sciences
Oxidative Stress
Psammomys obesus
Selenium
Trace Elements
type 2 diabetes mellitus
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The objective of this study is to investigate the relationship between altered plasma trace elements, particularly selenium (Se), with Hyper-homocysteinemia (HhCys) as a predictive factor of insulin secretion dysfunction. The study is carried out on adult Psammomys obesus, divided in 4 experimental groups: (I) Normoglycemic/Normoinsulinemic; (II) Normoglycemic/Hyperinsulinemic; (III) Hyperglycaemic/Hyperinsulinemic and (IV) Hyperglycaemic/Insulin deficiency with ketoacidosis. The data showed that a drastic depletion of Se plasma levels is positively correlated with HhCys (>15 µmol/L; p 
ISSN:1381-3455
1744-4160
DOI:10.1080/13813455.2020.1839501