Interference of altered plasma trace elements profile with hyperhomocysteinemia and oxidative stress damage to insulin secretion dysfunction in Psammomys obesus: focus on the selenium

The objective of this study is to investigate the relationship between altered plasma trace elements, particularly selenium (Se), with Hyper-homocysteinemia (HhCys) as a predictive factor of insulin secretion dysfunction. The study is carried out on adult Psammomys obesus, divided in 4 experimental...

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Published in:Archives of physiology and biochemistry 2023-03, Vol.129 (2), p.505-518
Main Authors: Bouazza, Asma, Fontaine, Eric, Leverve, Xavier, Koceir, Elhadj-Ahmed
Format: Article
Language:English
Subjects:
Animals
Diabetes Mellitus, Type 2 - metabolism
Gerbillinae - metabolism
Hyperglycemia - metabolism
hyperhomocysteine
Hyperhomocysteinemia
Insulin
Insulin Secretion
Life Sciences
Oxidative Stress
Psammomys obesus
Selenium
Trace Elements
type 2 diabetes mellitus
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creator Bouazza, Asma
Fontaine, Eric
Leverve, Xavier
Koceir, Elhadj-Ahmed
description The objective of this study is to investigate the relationship between altered plasma trace elements, particularly selenium (Se), with Hyper-homocysteinemia (HhCys) as a predictive factor of insulin secretion dysfunction. The study is carried out on adult Psammomys obesus, divided in 4 experimental groups: (I) Normoglycemic/Normoinsulinemic; (II) Normoglycemic/Hyperinsulinemic; (III) Hyperglycaemic/Hyperinsulinemic and (IV) Hyperglycaemic/Insulin deficiency with ketoacidosis. The data showed that a drastic depletion of Se plasma levels is positively correlated with HhCys (>15 µmol/L; p 
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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Animals
Diabetes Mellitus, Type 2 - metabolism
Gerbillinae - metabolism
Hyperglycemia - metabolism
hyperhomocysteine
Hyperhomocysteinemia
Insulin
Insulin Secretion
Life Sciences
Oxidative Stress
Psammomys obesus
Selenium
Trace Elements
type 2 diabetes mellitus
title Interference of altered plasma trace elements profile with hyperhomocysteinemia and oxidative stress damage to insulin secretion dysfunction in Psammomys obesus: focus on the selenium
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