Paraneoplastic Neurologic Symptoms in a Pediatric Patient with Hodgkin Lymphoma

Neurological paraneoplastic syndromes are exceedingly rare, and often difficult to recognize clinically. Paraneoplastic achalasia is a condition characterized by new-onset dysphagia that is unrelated to tumor burden, most often due to the development of auto-immune antibodies targeting esophageal ti...

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Bibliographic Details
Published in:Cancer investigation 2021-02, Vol.39 (2), p.159-162
Main Authors: Baniel, Claire C., Donaldson, Sarah S., Aftandilian, Catherine, Hiniker, Susan M.
Format: Article
Language:English
Subjects:
achalasia
Child
Disease Management
Endoscopy, Digestive System
Epstein-Barr Virus Infections - diagnosis
Epstein-Barr Virus Infections - diagnostic imaging
Female
Hodgkin Disease - diagnostic imaging
Hodgkin Disease - virology
Hodgkin lymphoma
Humans
Paraneoplastic syndrome
Paraneoplastic Syndromes - diagnostic imaging
Paraneoplastic Syndromes - etiology
pediatric cancers
Tomography, X-Ray Computed
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Description
Summary:Neurological paraneoplastic syndromes are exceedingly rare, and often difficult to recognize clinically. Paraneoplastic achalasia is a condition characterized by new-onset dysphagia that is unrelated to tumor burden, most often due to the development of auto-immune antibodies targeting esophageal tissue. Due to the rarity of this condition, diagnosis is often delayed, leading to increased time to treatment. Here we report a case of a rare paraneoplastic achalasia in a female child with EBV + Hodgkin lymphoma (HL), review literature describing paraneoplastic achalasia, and discuss treatment strategies for improving clinical outcome in these patients.
ISSN:0735-7907
1532-4192
DOI:10.1080/07357907.2020.1852412