PANCYTOPENIA SECONDARY TO AUTOIMMUNE VITAMIN B 12 DEFICIENCY IN GRAVES DISEASE

To describe a case of Graves disease (GD) and coexistent pancytopenia associated with autoimmune vitamin B deficiency. While thyrotoxicosis and antithyroid drugs can cause pancytopenia, other autoimmune conditions such as vitamin B deficiency can occur, leading to severe anemia and pancytopenia. A 1...

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Bibliographic Details
Published in:AACE clinical case reports 2020-11, Vol.6 (6), p.e282
Main Authors: Rodriguez, Vilmarie, Gonzales, Kristen M, Iqbal, Anoop Mohamed, Arbelo-Ramos, Natasha, Wyatt, Kirk D, Lteif, Aida N, Castro, M Regina
Format: Article
Language:English
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Summary:To describe a case of Graves disease (GD) and coexistent pancytopenia associated with autoimmune vitamin B deficiency. While thyrotoxicosis and antithyroid drugs can cause pancytopenia, other autoimmune conditions such as vitamin B deficiency can occur, leading to severe anemia and pancytopenia. A 19-year-old female with GD treated with methimazole presented with thyrotoxicosis and evidence of pancytopenia. Diagnostic studies included a complete blood cell count, peripheral blood smears, thyroid function tests, and a bone marrow biopsy. White blood cells were 2.4 × 10 cells/L (reference range [RR] is 3.4 to 9.6 × 10 cells/L), hemoglobin was 7.9 g/dL (RR is 11.6 to 15.0 g/dL), neutrophil count was 1.2 × 10 cells/L, and platelets were 84 × 10 cells/L (RR is 157 to 371 × 10 cells/L). Thyroid-stimulating hormone was
ISSN:2376-0605
DOI:10.4158/ACCR-2020-0055