New phenolics from Uraria crinita (L.) DC

Reinvestigation of a methanol extract of Uraria crinita afforded a new 3- hydroxyisoflavanone, 3,5,7,2',4'-pentahydroxyisoflavanone (1), two new monoaryl glucosides, 3,4-dimethoxyphenyl 1-O-(6′-O-acetyl)-β-D-glucopyranoside (2) and 3,4,5-trimethoxyphenyl 1-O-(6′-O-acetyl)-β-D-glucopyranosi...

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Bibliographic Details
Published in:Natural product research 2022-07, Vol.36 (13), p.3381-3388
Main Authors: Thien, Dao Duc, Tai, Bui Huu, Dai, Tran Duc, Sa, Nguyen Hoang, Thuy, Trinh Thi, Hoang Anh, Nguyen Thi, Tam, Nguyen Thanh
Format: Article
Language:English
Subjects:
Cell lines
Cytotoxicity
Glucosides
isoflavanone
monoaryl glucosides
NMR
Nuclear magnetic resonance
phenolics
Phenols
Uraria crinita
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Summary:Reinvestigation of a methanol extract of Uraria crinita afforded a new 3- hydroxyisoflavanone, 3,5,7,2',4'-pentahydroxyisoflavanone (1), two new monoaryl glucosides, 3,4-dimethoxyphenyl 1-O-(6′-O-acetyl)-β-D-glucopyranoside (2) and 3,4,5-trimethoxyphenyl 1-O-(6′-O-acetyl)-β-D-glucopyranoside (3), in addition to three known compounds, 3′-O-methylorobol (4), robusflavone B (5), and apigenin (6). The structural elucidation of these compounds was achieved by analyses of their spectroscopic data (HR-ESI-MS, 1 D- and 2 D-NMR) and acidic hydrolysis. The U. crinita extracts and compounds 1-6 exhibited weak or no cytotoxic activity against KB, HepG2, Lu and MCF7 cell lines.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1860973