Lipid larceny: channelizing host lipids for establishing successful pathogenesis by bacteria

• Published in: Virulence 2021-12, Vol.12 (1), p.195-216
• Main Authors: Chatterjee, Ritika, Chowdhury, Atish Roy, Mukherjee, Debapriya, Chakravortty, Dipshikha
• Format: Article
• Language: English
• Subjects: anti-inflammatory; bacterial clearance; bacterial infection; bacterial toxin; cholesterols; extracellular bacteria; gram-negative; Gram-positive; immunomodulation; intracellular survival; invasion; lipid droplet; lipid rafts; proinflammatory; Review; signaling; sphingolipids; therapeutics; virulence
• ISSN: 2150-5594; 2150-5608
• DOI: 10.1080/21505594.2020.1869441

Lipids are complex organic compounds made up of carbon, oxygen, and hydrogen. These play a diverse and intricate role in cellular processes like membrane trafficking, protein sorting, signal transduction, and bacterial infections. Both Gram-positive bacteria (Staphylococcus sp., Listeria monocytogenes, etc.) and Gram-negative bacteria (Chlamydia sp., Salmonella sp., E. coli, etc.) can hijack the various host-lipids and utilize them structurally as well as functionally to mount a successful infection. The pathogens can deploy with various arsenals to exploit host membrane lipids and lipid-associated receptors as an attachment for toxins' landing or facilitate their entry into the host cellular niche. Bacterial species like Mycobacterium sp. can also modulate the host lipid metabolism to fetch its carbon source from the host. The sequential conversion of host membrane lipids into arachidonic acid and prostaglandin E2 due to increased activity of cPLA-2 and COX-2 upon bacterial infection creates immunosuppressive conditions and facilitates the intracellular growth and proliferation of bacteria. However, lipids' more debatable role is that they can also be a blessing in disguise. Certain host-lipids, especially sphingolipids, have been shown to play a crucial antibacterial role and help the host in combating the infections. This review shed light on the detailed role of host lipids in bacterial infections and the current understanding of the lipid in therapeutics. We have also discussed potential prospects and the need of the hour to help us cope in this race against deadly pathogens and their rapidly evolving stealthy virulence strategies.