Pro-inflammatory cytokines as potential predictors for intradialytic hypotension

• Published in: Renal failure 2021-01, Vol.43 (1), p.198-205
• Main Authors: Yu, Jinbo, Chen, Xiaohong, Li, Yang, Wang, Yaqiong, Cao, Xuesen, Liu, Zhonghua, Shen, Bo, Zou, Jianzhou, Ding, Xiaoqiang
• Format: Article
• Language: English
• Subjects: Blood pressure; Clinical Study; Correlation analysis; Cytokines; Hemodialysis; Hypotension; IL-1β; Immune response; Inflammation; interleukin-1β; Intradialytic hypotension; pro-inflammatory cytokines; Risk factors; Tumor necrosis factor-TNF; Tumor necrosis factor-α
• ISSN: 0886-022X; 1525-6049
• DOI: 10.1080/0886022X.2021.1871921

Intradialytic hypotension (IDH) is a common complication in maintaining hemodialysis (MHD) patients. Immune activation might be part of the mechanisms. However, the association between pro-inflammatory cytokines and blood pressure (BP) has not been deeply explored. So we aim to evaluate the potential role of pro-inflammatory cytokines in IDH. MHD patients starting hemodialysis before January 2016 were enrolled in our retrospective study. Patients' characteristics, laboratory results, and intradialytic BP were collected. IDH was defined as nadir systolic BP ≤ 90 mmHg during hemodialysis. The definition of IDH group was that those who suffered from more than one hypotensive event during one month after the enrollment (10% of dialysis treatments). Spearman correlation analysis and logistic regression were employed to explore the relationship between pro-inflammatory cytokines and IDH. Among 390 patients, 72 were identified with IDH (18.5%). High levels of serum tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were observed in the IDH group (p