Acridone alkaloids and flavones from the leaves of Citrus reticulata

A new acridone alkaloid, reticarcidone A (1), decorated with an oxygenated isopentenyl group between C-1 and C-2, was isolated from the leaves of Citrus reticulata Blanco, together with nine known acridone alkaloids (2-10) and fifteen flavones compounds (11-25). The structure of those compounds were...

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Bibliographic Details
Published in:Natural product research 2022-07, Vol.36 (14), p.3644-3650
Main Authors: Ye, Ye, Xu, Gang, Li, Dong-Liang
Format: Article
Language:English
Subjects:
acridone alkaloids
Alkaloids
Citrus reticulata
cytotoxic activity
Cytotoxicity
Flavones
NMR
Nuclear magnetic resonance
Toxicity
Tumor cell lines
Tumors
Two dimensional analysis
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Summary:A new acridone alkaloid, reticarcidone A (1), decorated with an oxygenated isopentenyl group between C-1 and C-2, was isolated from the leaves of Citrus reticulata Blanco, together with nine known acridone alkaloids (2-10) and fifteen flavones compounds (11-25). The structure of those compounds were confirmed by analysis of comprehensive 1D and 2D NMR, and MS data. Reticarcidone A (1) was the first pyrano[2,3-a]acridone isolated from the genus Citrus. Some of these compounds showed moderated cytotoxicity against the five human tumor cell lines MCF-7, SMMC-7721, HL-60, A549 and SW480.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.1876047