Impact of prompt gamma emission of 44 Sc on quantification in preclinical and clinical PET systems

Sc is an increasingly investigated positron emitter for use in positron emission tomography (PET) imaging. However, Sc is a non-pure positron emitter, since prompt photons are co-emitted during the decay process. This study investigates coincidence energy spectra of Sc and its impact on PET quantifi...

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Bibliographic Details
Published in:Applied radiation and isotopes 2021-04, Vol.170, p.109599
Main Authors: Rosar, Florian, Bohnenberger, Hendrik, Moon, Euy Sung, Rösch, Frank, Denig, Achim, Vincenz-Zörner, Daniel, Hoffmann, Manuela A, Khreish, Fadi, Ezziddin, Samer, Schreckenberger, Mathias, Buchholz, Hans-Georg, Schaefer-Schuler, Andrea
Format: Article
Language:English
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Summary:Sc is an increasingly investigated positron emitter for use in positron emission tomography (PET) imaging. However, Sc is a non-pure positron emitter, since prompt photons are co-emitted during the decay process. This study investigates coincidence energy spectra of Sc and its impact on PET quantification on a preclinical and clinical PET system in comparison with F. The raw data of the coincidence events revealed characteristic differences comparing the photon energy distribution of Sc and F. Due to prompt gamma emission of Sc, activity recovery is underestimated on PET systems. However, clinical PET imaging of Sc with acceptable quantitative accuracy appears feasible by using a single, constant correction factor.
ISSN:1872-9800
DOI:10.1016/j.apradiso.2021.109599