Efficacy and predictive factors of cyclosporine A in alopecia areata: a systematic review with meta-analysis

Drugs for alopecia areata (AA) can induce hair regrowth, but do not change the disease course. Dual properties of cyclosporine A (CsA) as hypetrichotic and immunosuppressive agent have encouraged use in AA. We aimed to determine the most meaningful efficacy of CsA and reveal features helping enhance...

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Bibliographic Details
Published in:The Journal of dermatological treatment 2022-04, Vol.33 (3), p.1643-1651
Main Authors: Husein-ElAhmed, Husein, Steinhoff, Martin
Format: Article
Language:English
Subjects:
alopecia areata
Cyclosporine
efficacy
recurrence
treatment regimen
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Summary:Drugs for alopecia areata (AA) can induce hair regrowth, but do not change the disease course. Dual properties of cyclosporine A (CsA) as hypetrichotic and immunosuppressive agent have encouraged use in AA. We aimed to determine the most meaningful efficacy of CsA and reveal features helping enhance its efficacy and reduce relapses. Efficacy of CsA and predictive factors were investigated. Cochrane, MEDLINE, Pubmed and Embase databases were searched. 2,189 papers were retrieved. Based on 344 patients, mean proportion of responders was 73%. CsA monotherapy showed proportion of hair regrowth of 66%, whereas CsA combined with systemic corticosteroids yielded 78%. Overall efficacy in studies with duration of CsA treatment
ISSN:0954-6634
1471-1753
DOI:10.1080/09546634.2021.1886230