Two new polycyclic polyprenylated acylphloroglucinols derivatives from Hypericum acmosepalum

Polycyclic polyprenylated acylphloroglucinols (PPAPs) were mainly obtained from the plants of genus of Guttiferae family, and possessed intriguing chemical structures and appealing biological activities. Two new PPAPs derivatives, hyperacmosin C ( ) and hyperacmosin D ( ) were isolated from . Their...

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Bibliographic Details
Published in:Journal of asian natural products research 2021-02, p.1
Main Authors: Suo, Xin-Yue, Shi, Meng-Jiao, Dang, Jun, Yue, Hui-Lan, Tao, Yan-Duo, Zhen, Bo, Wang, Jia-Jia, Wang, Xue, Sun, Hao-Ran, Sun, Hua, Qiang, Gui-Fen, Ji, Teng-Fei, Liu, Bo
Format: Article
Language:English
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Summary:Polycyclic polyprenylated acylphloroglucinols (PPAPs) were mainly obtained from the plants of genus of Guttiferae family, and possessed intriguing chemical structures and appealing biological activities. Two new PPAPs derivatives, hyperacmosin C ( ) and hyperacmosin D ( ) were isolated from . Their structures were established by NMR, HREIMS, and experimental electronic circular dichroism spectra. Besides, compound showed significant hepatoprotective activity at 10 µM against paracetamol-induced HepG2 cell damage and compound could moderately increase the relative glucose consumption.
ISSN:1477-2213