Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer

Widespread mammographic screening programs and improved self-monitoring allow for breast cancer to be detected earlier than ever before. Breast-conserving surgery is a successful treatment for select women. However, up to 40% of women develop local recurrence after surgery despite apparently tumor-f...

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Bibliographic Details
Published in:NPJ breast cancer 2020-08, Vol.6 (1), p.38
Main Authors: Gadaleta, Emanuela, Fourgoux, Pauline, Pirró, Stefano, Thorn, Graeme J, Nelan, Rachel, Ironside, Alastair, Rajeeve, Vinothini, Cutillas, Pedro R, Lobley, Anna E, Wang, Jun, Gea, Esteban, Ross-Adams, Helen, Bessant, Conrad, Lemoine, Nicholas R, Jones, Louise J, Chelala, Claude
Format: Article
Language:English
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Summary:Widespread mammographic screening programs and improved self-monitoring allow for breast cancer to be detected earlier than ever before. Breast-conserving surgery is a successful treatment for select women. However, up to 40% of women develop local recurrence after surgery despite apparently tumor-free margins. This suggests that morphologically normal breast may harbor early alterations that contribute to increased risk of cancer recurrence. We conducted a comprehensive transcriptomic and proteomic analysis to characterize 57 fresh-frozen tissues from breast cancers and matched histologically normal tissues resected proximal to (
ISSN:2374-4677
2374-4677