Correlations between whole body volumetric parameters of 68 Ga-PSMA PET/CT and biochemical-histopathological parameters in castration-naive and resistant prostate cancer patients

• Published in: Annals of nuclear medicine 2021-05, Vol.35 (5), p.540
• Main Authors: Yildirim, Özgen Ahmet, Gündoğan, Cihan, Can, Canan, Poyraz, Kerem, Erdur, Erkan, Kömek, Halil
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Edetic Acid - analogs & derivatives; Gallium Isotopes; Gallium Radioisotopes; Humans; Male; Middle Aged; Neoplasm Grading; Oligopeptides; Positron Emission Tomography Computed Tomography; Prostate-Specific Antigen - blood; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - pathology; Prostatic Neoplasms, Castration-Resistant - diagnostic imaging; Prostatic Neoplasms, Castration-Resistant - pathology; Retrospective Studies; Whole Body Imaging
• ISSN: 1864-6433

To evaluate the relationship between whole body volumetric (Wbv) results of Ga-PSMA PET/CT with biochemical and histopathological parameters. One hundred twenty-one prostate cancer patients who underwent Ga-PSMA PET/CT between January 2018 and December 2019 were included. Imaging was conducted for staging upon new diagnosis with moderate- and high-risk disease and for confirming the progression of castration resistance. The relationships between the Wbv Ga-PSMA PET/CT parameters and prostate-specific antigen (PSA) levels, PSA doubling time and Gleason score (GS) were evaluated. The median GS and mean PSA levels were similar between the castration-naive and resistant patients. The PSA levels were positively correlated with MTVwb (p: 0.009, r: 0.286) and TLPwb (p: 0.002, r: 0.344). Gleason scores were positively correlated with MTVwb (p: 0.050, r: 0.216), TLPwb (p: 0.007, r: 0.296) and highest standard uptake value (HSUV) max (p: 0.047, r: 0.220). In the castration-naive group, Gleason scores (from p  2 years (n = 35) (p = 0.046, 0.047 and 0.042, respectively). Wbv Ga-PSMA PET/CT results were correlated with PSA levels and Gleason scores. The correlation was relatively stronger in the castration-naive group. The prognostic accuracy of PSA in the resistant group may be weaker than in the naive group. The difference in volumetric parameters of patients with short BR compared to long BR supports the idea that Ga-PSMA PET/CT can distinguish patients with rapid relapse from others.