Clinical evidence of dietary supplementation with sesame on cardiovascular risk factors: An updated meta-analysis of randomized controlled trials

The present analysis was to summarize the evidence of the effects of sesame and its derivatives supplementation on cardiovascular disease (CVD) risk factors by performing a meta-analysis of randomized controlled trials (RCTs). Electronic databases were searched from their inception to July 2020. Two...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2022-07, Vol.62 (20), p.5592-5602
Main Authors: Huang, Haohai, Zhou, Guanghui, Pu, Rong, Cui, Yejia, Liao, Dan
Format: Article
Language:English
Subjects:
Bias
Blood pressure
Body mass
Body mass index
Body size
Body weight
Cardiovascular diseases
Cholesterol
Clinical trials
Confidence intervals
CVD
Diet
Dietary supplements
Health risks
Heart diseases
Heterogeneity
lipid
Lipids
Meta-analysis
Risk analysis
Risk factors
Sensitivity analysis
sesame
Sesamum
Statistical analysis
Statistics
Subgroups
Triglycerides
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Summary:The present analysis was to summarize the evidence of the effects of sesame and its derivatives supplementation on cardiovascular disease (CVD) risk factors by performing a meta-analysis of randomized controlled trials (RCTs). Electronic databases were searched from their inception to July 2020. Two investigators independently assessed articles for inclusion, extracted data, and statistical analysis. The quality of included articles was assessed according to the Cochrane risk of bias tool. Major outcomes were synthesized using a random effect model and presented as weighted mean difference and 95% confidence interval. Heterogeneity, subgroup analyses, sensitivity analysis, meta-regression, and publication bias were also conducted. The GRADE approach was used to evaluate the quality of evidence. Overall, 16 trials involving 908 participants were included for statistical pooling. Compared with the control group, sesame intake significantly decreased the levels of total cholesterol, triglycerides, systolic blood pressure, diastolic blood pressure, body weight, body mass index, hip circumference, and waist circumference (P 
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2021.1888689