Neuroprotective validation of pectin in T2DM-induced allodynia and hyperalgesia in diabetic peripheral neuropathic pain

To validate neuroprotective effect of pectin against neuropathic pain in diabetic rodents. Pectin was isolated and characterised from different sources to validate its neuroprotective effect against T2DM associated neuropathic pain. The antioxidant activity of pectins was done by the DPPH method. Ty...

Full description

Saved in:
Bibliographic Details
Published in:Archives of physiology and biochemistry 2023-07, Vol.129 (4), p.901-912
Main Authors: Srivastava, Rajnish, Tripathi, Laxmi, Swain, Sudhansu Ranjan, Singh, Jagan
Format: Article
Language:English
Subjects:
antioxidant
diabetic neuropathy
Neuroprotective
pectin
streptozotocin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To validate neuroprotective effect of pectin against neuropathic pain in diabetic rodents. Pectin was isolated and characterised from different sources to validate its neuroprotective effect against T2DM associated neuropathic pain. The antioxidant activity of pectins was done by the DPPH method. Type-2 diabetes mellitus (T2DM) was induced in Wistar albino rats by high-fat diet and high-fat emulsion feeding for 2 weeks followed by a single i.p. of Sterptozotocin in 3rd week. The animals were grouped as positive control and Citrus sinensis (L.) Osbeck peel pectin (CSL-OP) as test group and treated for the next 4 weeks. Body weight and blood glucose were measured up to 8 weeks; however, behavioural assessment was done at the end of 5th to 8th week. CSL-OP restored the reduced body weight and elevated blood glucose with increased pain threshold and improved walking performance. CSL-OP prevented progression of early diabetic neuropathy with anti-oxidant activity.
ISSN:1381-3455
1744-4160
DOI:10.1080/13813455.2021.1884725