Peripheral blood markers of sepsis in foals born from mares with experimentally induced ascending placentitis

Neonatal sepsis is a leading cause of neonatal death during the first-week postfoaling. Despite recent advancements in the diagnosis and treatment of sepsis in the newborn foal, the non-specific clinical signs and subtle nature of this disease may result in delayed diagnosis until severe progression...

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Bibliographic Details
Published in:Veterinary record 2020-07, Vol.187 (1), p.29
Main Authors: Borba, Luciana de Araujo, Nogueira, Carlos Eduardo Wayne, Bruhn, Fábio Raphael Pascoti, da Silva, Gabriela Castro, Feijó, Lorena Soares, Canisso, Igor F, Curcio, Bruna da Rosa
Format: Article
Language:English
Subjects:
alpha-Fetoproteins - analysis
Animals
Animals, Newborn - blood
Biomarkers - blood
Case-Control Studies
Female
Horse Diseases - blood
Horses
Parturition
Placenta Diseases - etiology
Placenta Diseases - veterinary
Pregnancy
Sepsis - blood
Sepsis - veterinary
Serum Amyloid A Protein - analysis
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Summary:Neonatal sepsis is a leading cause of neonatal death during the first-week postfoaling. Despite recent advancements in the diagnosis and treatment of sepsis in the newborn foal, the non-specific clinical signs and subtle nature of this disease may result in delayed diagnosis until severe progression of the disease; thus, early detection of sepsis remains critical for a favourable outcome. This study aimed to identify early blood markers as predictive of sepsis on foals. Thirty-five foals were allocated into three groups: healthy control foals (n=7) and foals born from mares with placentitis: septic foals (n=9) and non-septic foals (n=19). Blood samples were obtained immediately after foaling and at 12, 24 and 48 hours. All samples were assessed for glucose, lactate, triglycerides, total cholesterol, urea, creatinine, total solids, fibrinogen, gamma-glutamyl transferase (GGT), serum amyloid A (SAA) and alpha-fetoprotein (AFP) concentrations. At foaling, glucose and GGT concentrations were lower in septic foals (P
ISSN:2042-7670