Relation of Serum Ferritin Level with Serum Hepcidin and Fucose Levels in Children with β-Thalassemia Major

The aim of this study was to assess serum ferritin, hepcidin, L-fucose, and protein binding fucose levels in β-thalassemia major (β-TM) patients and to correlate the serum ferritin level with hepcidin and fucose levels. A total 70 (26 males and 44 females) children with β-TM, ages ranging from 5 to...

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Bibliographic Details
Published in:Hemoglobin 2021-01, Vol.45 (1), p.69-73
Main Authors: AL-Zuhairy, Salah H., Darweesh, Mohammed A., Othman, Mohammed A-M.
Format: Article
Language:English
Subjects:
Adolescent
beta-Thalassemia
Biomarkers
Child
Child, Preschool
Female
ferritin
Ferritins
Fucose
hepcidin
Hepcidins
Humans
Iron - metabolism
Iron Overload
Male
β-Thalassemia major (β-TM)
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Summary:The aim of this study was to assess serum ferritin, hepcidin, L-fucose, and protein binding fucose levels in β-thalassemia major (β-TM) patients and to correlate the serum ferritin level with hepcidin and fucose levels. A total 70 (26 males and 44 females) children with β-TM, ages ranging from 5 to 16 years (mean age 8.3 ± 2.7 years) and 50 (25 males and 25 females) apparently healthy subjects with matching age and sex were included as a control group. An especially designed questionnaire was used to collect age, gender, body mass index (BMI), hemoglobin (Hb), serum ferritin, hepcidin-25 peptide, α-L-fucose, and protein binding fucose (PBF) levels. β-Thalassemia major patients had significantly (p 
ISSN:0363-0269
1532-432X
DOI:10.1080/03630269.2021.1898419