Simultaneous assessment of coronary flow reserve and left ventricular function during vasodilator stress evaluated by 13 N-ammonia hybrid PET/MRI

To explore changes in left ventricular (LV) function and the relationship of these changes with myocardial blood flow (MBF) evaluated by N-ammonia hybrid positron-emission tomography (PET)/magnetic resonance imaging (MRI) during vasodilator stress in patients with suspected coronary artery disease (...

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Bibliographic Details
Published in:Clinical radiology 2021-06, Vol.76 (6), p.472.e1
Main Authors: Kiko, T, Yokokawa, T, Masuda, A, Misaka, T, Yamada, S, Kaneshiro, T, Oikawa, M, Yoshihisa, A, Nakazato, K, Takeishi, Y
Format: Article
Language:English
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Summary:To explore changes in left ventricular (LV) function and the relationship of these changes with myocardial blood flow (MBF) evaluated by N-ammonia hybrid positron-emission tomography (PET)/magnetic resonance imaging (MRI) during vasodilator stress in patients with suspected coronary artery disease (CAD). Fifty-two consecutive patients with suspected CAD, who underwent N-ammonia PET/MRI, were enrolled. Vasodilator stress was induced by intravenous injection of adenosine. MBF and coronary flow reserve (CFR) were calculated from dynamic acquisition of N-ammonia PET. LV function was evaluated by MRI both at rest and during vasodilator stress. An abnormal perfusion on myocardial images was defined as a summed difference score of ≥4. MRI showed that the LV end-diastolic volume, LV end-systolic volume, and LV ejection fraction (LVEF) remained unchanged during vasodilator stress in all patients (n=52) as well as in the patients with CFR of
ISSN:1365-229X