Leishmanicidal activities of biosynthesized BaCO 3 (witherite) nanoparticles and their biocompatibility with macrophages

The aim of this study was cost-effective and greener synthesis of barium carbonate (BaCO or witherite) nanoparticles with economic importance, and to evaluate their therapeutic potentials and biocompatibility with immune cells. Barium carbonate nanoparticles were biosynthesized using black elderberr...

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Bibliographic Details
Published in:Bioprocess and biosystems engineering 2021-09, Vol.44 (9), p.1957
Main Authors: Hashemi, Nooshin, Alijani, Hajar Q, Mousazadeh, Farideh, Rahi, Sadegh, Darijani, Samaneh, Sharifi, Fatemeh, Khalili, Hakimeh, Iravani, Siavash, Borhani, Fariba, Zafarnia, Niloofar, Khatami, Mehrdad
Format: Article
Language:English
Subjects:
Animals
Antiprotozoal Agents - chemical synthesis
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - pharmacology
Barium - chemistry
Barium - pharmacology
Carbonates - chemistry
Carbonates - pharmacology
Cell Line
Leishmania tropica - growth & development
Macrophages - metabolism
Macrophages - parasitology
Materials Testing
Mice
Nanoparticles - chemistry
Nanoparticles - therapeutic use
Plant Extracts - chemistry
Sambucus - chemistry
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Summary:The aim of this study was cost-effective and greener synthesis of barium carbonate (BaCO or witherite) nanoparticles with economic importance, and to evaluate their therapeutic potentials and biocompatibility with immune cells. Barium carbonate nanoparticles were biosynthesized using black elderberry extract in one step with non-toxic precursors and simple laboratory conditions; their morphologies and specific structures were analyzed using field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX). The therapeutic capabilities of these nanoparticles on the immune cells of murine macrophages J774 and promastigotes Leishmania tropica were evaluated. BaCO nanoparticles with IC  = 46.6 µg/mL were more effective than negative control and glucantium (positive control) in reducing promastigotes (P 
ISSN:1615-7605