Chromatin Remodeling in the Brain-a NuRD evelopmental Odyssey

During brain development, the genome must be repeatedly reconfigured in order to facilitate neuronal and glial differentiation. A host of chromatin remodeling complexes facilitates this process. At the genetic level, the non-redundancy of these complexes suggests that neurodevelopment may require a...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-04, Vol.22 (9)
Main Authors: Larrigan, Sarah, Shah, Sujay, Fernandes, Alex, Mattar, Pierre
Format: Article
Language:English
Online Access:Get full text
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Summary:During brain development, the genome must be repeatedly reconfigured in order to facilitate neuronal and glial differentiation. A host of chromatin remodeling complexes facilitates this process. At the genetic level, the non-redundancy of these complexes suggests that neurodevelopment may require a lexicon of remodelers with different specificities and activities. Here, we focus on the nucleosome remodeling and deacetylase (NuRD) complex. We review NuRD biochemistry, genetics, and functions in neural progenitors and neurons.
ISSN:1422-0067
DOI:10.3390/ijms22094768