Heart transplantation from donors with left ventricular ejection fraction under 40

Heart transplantation (HTx) remains the treatment of choice for patients with end-stage advanced heart failure. In 2016 the Schumakov National Medical Research Center commenced performing HTx from donors with abnormal left ventricular systolic function (LVEF 60%). The use of dysfunctional donor hear...

Full description

Saved in:
Bibliographic Details
Published in:Clinical transplantation 2021-05, p.e14341
Main Authors: Poptsov, Vitalii, Khatutskiy, Valery, Skokova, Anastasiia, Krasivskyi, Ihor, Sabashnikov, Anton, Merkle-Storms, Julia, Spirina, Ekaterina
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue
container_start_page e14341
container_title Clinical transplantation
container_volume
creator Poptsov, Vitalii
Khatutskiy, Valery
Skokova, Anastasiia
Krasivskyi, Ihor
Sabashnikov, Anton
Merkle-Storms, Julia
Spirina, Ekaterina
description Heart transplantation (HTx) remains the treatment of choice for patients with end-stage advanced heart failure. In 2016 the Schumakov National Medical Research Center commenced performing HTx from donors with abnormal left ventricular systolic function (LVEF 60%). The use of dysfunctional donor hearts with impaired LV systolic function may be a realistic approach for expanding the donor pool. However, organs from such donors should be used for recipient cohorts requiring an urgent HTx, particularly for those with pretransplant mechanical circulatory support allowing for hemodynamic support in cases of early graft dysfunction in the post-transplant period.
format article
fullrecord <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_33949006</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>33949006</sourcerecordid><originalsourceid>FETCH-pubmed_primary_339490063</originalsourceid><addsrcrecordid>eNqFjssKwjAQAIMgtj5-QfYHhNTUQs6i9Czey9puMSVNyiZV_HsF69nTzGEOMxNpprTeSZntE7EMoftYkRWHhUiU0rmWskjFpSTkCJHRhcGiixiNd9Cy76HxznOAp4l3sNRGeJCLbOrRIgN1VE8pfmV0DTHkci3mLdpAm4krsT2frsdyN4y3nppqYNMjv6rfhPobvAGg6D2i</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Heart transplantation from donors with left ventricular ejection fraction under 40</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Poptsov, Vitalii ; Khatutskiy, Valery ; Skokova, Anastasiia ; Krasivskyi, Ihor ; Sabashnikov, Anton ; Merkle-Storms, Julia ; Spirina, Ekaterina</creator><creatorcontrib>Poptsov, Vitalii ; Khatutskiy, Valery ; Skokova, Anastasiia ; Krasivskyi, Ihor ; Sabashnikov, Anton ; Merkle-Storms, Julia ; Spirina, Ekaterina</creatorcontrib><description>Heart transplantation (HTx) remains the treatment of choice for patients with end-stage advanced heart failure. In 2016 the Schumakov National Medical Research Center commenced performing HTx from donors with abnormal left ventricular systolic function (LVEF &lt;40%). The aim of this study was to evaluate early and late outcomes of recipients after HTx from donors with abnormal LV systolic function. 487 patients underwent HTx in our institution from January 2016 to December 2018. 27 (5.5%) patients were transplanted using cardiac allografts from donors with LVEF &lt; 40%. A total of 47 donors with LVEF &lt; 40% were evaluated for potential donation. Most heart donors revealed a left ventricular ejection fraction ranging between 30% to 40%. Twenty-five recipients required urgent HTx. Four recipients presented with early allograft dysfunction. All surviving recipients demonstrated early (85.2%) or delayed (14.8%) recovery of systolic function (LVEF&gt;60%). The use of dysfunctional donor hearts with impaired LV systolic function may be a realistic approach for expanding the donor pool. However, organs from such donors should be used for recipient cohorts requiring an urgent HTx, particularly for those with pretransplant mechanical circulatory support allowing for hemodynamic support in cases of early graft dysfunction in the post-transplant period.</description><identifier>EISSN: 1399-0012</identifier><identifier>PMID: 33949006</identifier><language>eng</language><publisher>Denmark</publisher><ispartof>Clinical transplantation, 2021-05, p.e14341</ispartof><rights>This article is protected by copyright. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-6289-1035</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33949006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Poptsov, Vitalii</creatorcontrib><creatorcontrib>Khatutskiy, Valery</creatorcontrib><creatorcontrib>Skokova, Anastasiia</creatorcontrib><creatorcontrib>Krasivskyi, Ihor</creatorcontrib><creatorcontrib>Sabashnikov, Anton</creatorcontrib><creatorcontrib>Merkle-Storms, Julia</creatorcontrib><creatorcontrib>Spirina, Ekaterina</creatorcontrib><title>Heart transplantation from donors with left ventricular ejection fraction under 40</title><title>Clinical transplantation</title><addtitle>Clin Transplant</addtitle><description>Heart transplantation (HTx) remains the treatment of choice for patients with end-stage advanced heart failure. In 2016 the Schumakov National Medical Research Center commenced performing HTx from donors with abnormal left ventricular systolic function (LVEF &lt;40%). The aim of this study was to evaluate early and late outcomes of recipients after HTx from donors with abnormal LV systolic function. 487 patients underwent HTx in our institution from January 2016 to December 2018. 27 (5.5%) patients were transplanted using cardiac allografts from donors with LVEF &lt; 40%. A total of 47 donors with LVEF &lt; 40% were evaluated for potential donation. Most heart donors revealed a left ventricular ejection fraction ranging between 30% to 40%. Twenty-five recipients required urgent HTx. Four recipients presented with early allograft dysfunction. All surviving recipients demonstrated early (85.2%) or delayed (14.8%) recovery of systolic function (LVEF&gt;60%). The use of dysfunctional donor hearts with impaired LV systolic function may be a realistic approach for expanding the donor pool. However, organs from such donors should be used for recipient cohorts requiring an urgent HTx, particularly for those with pretransplant mechanical circulatory support allowing for hemodynamic support in cases of early graft dysfunction in the post-transplant period.</description><issn>1399-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFjssKwjAQAIMgtj5-QfYHhNTUQs6i9Czey9puMSVNyiZV_HsF69nTzGEOMxNpprTeSZntE7EMoftYkRWHhUiU0rmWskjFpSTkCJHRhcGiixiNd9Cy76HxznOAp4l3sNRGeJCLbOrRIgN1VE8pfmV0DTHkci3mLdpAm4krsT2frsdyN4y3nppqYNMjv6rfhPobvAGg6D2i</recordid><startdate>20210504</startdate><enddate>20210504</enddate><creator>Poptsov, Vitalii</creator><creator>Khatutskiy, Valery</creator><creator>Skokova, Anastasiia</creator><creator>Krasivskyi, Ihor</creator><creator>Sabashnikov, Anton</creator><creator>Merkle-Storms, Julia</creator><creator>Spirina, Ekaterina</creator><scope>NPM</scope><orcidid>https://orcid.org/0000-0002-6289-1035</orcidid></search><sort><creationdate>20210504</creationdate><title>Heart transplantation from donors with left ventricular ejection fraction under 40</title><author>Poptsov, Vitalii ; Khatutskiy, Valery ; Skokova, Anastasiia ; Krasivskyi, Ihor ; Sabashnikov, Anton ; Merkle-Storms, Julia ; Spirina, Ekaterina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_339490063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poptsov, Vitalii</creatorcontrib><creatorcontrib>Khatutskiy, Valery</creatorcontrib><creatorcontrib>Skokova, Anastasiia</creatorcontrib><creatorcontrib>Krasivskyi, Ihor</creatorcontrib><creatorcontrib>Sabashnikov, Anton</creatorcontrib><creatorcontrib>Merkle-Storms, Julia</creatorcontrib><creatorcontrib>Spirina, Ekaterina</creatorcontrib><collection>PubMed</collection><jtitle>Clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poptsov, Vitalii</au><au>Khatutskiy, Valery</au><au>Skokova, Anastasiia</au><au>Krasivskyi, Ihor</au><au>Sabashnikov, Anton</au><au>Merkle-Storms, Julia</au><au>Spirina, Ekaterina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heart transplantation from donors with left ventricular ejection fraction under 40</atitle><jtitle>Clinical transplantation</jtitle><addtitle>Clin Transplant</addtitle><date>2021-05-04</date><risdate>2021</risdate><spage>e14341</spage><pages>e14341-</pages><eissn>1399-0012</eissn><abstract>Heart transplantation (HTx) remains the treatment of choice for patients with end-stage advanced heart failure. In 2016 the Schumakov National Medical Research Center commenced performing HTx from donors with abnormal left ventricular systolic function (LVEF &lt;40%). The aim of this study was to evaluate early and late outcomes of recipients after HTx from donors with abnormal LV systolic function. 487 patients underwent HTx in our institution from January 2016 to December 2018. 27 (5.5%) patients were transplanted using cardiac allografts from donors with LVEF &lt; 40%. A total of 47 donors with LVEF &lt; 40% were evaluated for potential donation. Most heart donors revealed a left ventricular ejection fraction ranging between 30% to 40%. Twenty-five recipients required urgent HTx. Four recipients presented with early allograft dysfunction. All surviving recipients demonstrated early (85.2%) or delayed (14.8%) recovery of systolic function (LVEF&gt;60%). The use of dysfunctional donor hearts with impaired LV systolic function may be a realistic approach for expanding the donor pool. However, organs from such donors should be used for recipient cohorts requiring an urgent HTx, particularly for those with pretransplant mechanical circulatory support allowing for hemodynamic support in cases of early graft dysfunction in the post-transplant period.</abstract><cop>Denmark</cop><pmid>33949006</pmid><orcidid>https://orcid.org/0000-0002-6289-1035</orcidid></addata></record>
fulltext fulltext
identifier EISSN: 1399-0012
ispartof Clinical transplantation, 2021-05, p.e14341
issn 1399-0012
language eng
recordid cdi_pubmed_primary_33949006
source Wiley-Blackwell Read & Publish Collection
title Heart transplantation from donors with left ventricular ejection fraction under 40
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T18%3A34%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Heart%20transplantation%20from%20donors%20with%20left%20ventricular%20ejection%20fraction%20under%2040&rft.jtitle=Clinical%20transplantation&rft.au=Poptsov,%20Vitalii&rft.date=2021-05-04&rft.spage=e14341&rft.pages=e14341-&rft.eissn=1399-0012&rft_id=info:doi/&rft_dat=%3Cpubmed%3E33949006%3C/pubmed%3E%3Cgrp_id%3Ecdi_FETCH-pubmed_primary_339490063%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/33949006&rfr_iscdi=true