Functional Divergence of Mammalian TFAP2a and TFAP2b Transcription Factors for Bidirectional Sleep Control

Here, Hu et al. show that AP-2 transcription factors have diverged to take on bidirectional control of sleep in mammals. This is the first instance where a sleep gene is shown to have diversified in evolution ...

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Bibliographic Details
Published in:Genetics (Austin) 2020-11, Vol.216 (3), p.735
Main Authors: Hu, Yang, Korovaichuk, Alejandra, Astiz, Mariana, Schroeder, Henning, Islam, Rezaul, Barrenetxea, Jon, Fischer, Andre, Oster, Henrik, Bringmann, Henrik
Format: Article
Language:English
Online Access:Get full text
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Summary:Here, Hu et al. show that AP-2 transcription factors have diverged to take on bidirectional control of sleep in mammals. This is the first instance where a sleep gene is shown to have diversified in evolution ...
ISSN:1943-2631
DOI:10.1534/genetics.120.303533