The effect of lymph node ratio on survival in non-small-cell lung cancer

The aim of this study was to evaluate the effect of prognostic factors and lymph node ratio (LNR) on survival in patients with resected non-small-cell lung cancer (NSCLC). Data from 421 patients with NSCLC who underwent complete resection between 2009 and 2015 were evaluated retrospectively. LNR was...

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Bibliographic Details
Published in:Acta chirurgica belgica 2023-01, Vol.123 (1), p.36-42
Main Authors: Sezen, Celal Bugra, Kalafat, Cem Emrah, Doğru, Mustafa Vedat, Aker, Cemal, Erdogu, Volkan, Saydam, Ozkan, Metin, Muzaffer
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Non-Small-Cell Lung - pathology
Humans
Lung cancer staging
Lung Neoplasms - pathology
Lymph Node Excision
Lymph Node Ratio
Lymph Nodes - pathology
Neoplasm Staging
non-small cell lung cancer
Prognosis
Retrospective Studies
survival
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Summary:The aim of this study was to evaluate the effect of prognostic factors and lymph node ratio (LNR) on survival in patients with resected non-small-cell lung cancer (NSCLC). Data from 421 patients with NSCLC who underwent complete resection between 2009 and 2015 were evaluated retrospectively. LNR was defined as the ratio of positive lymph nodes to the total number of lymph nodes removed. Associations between overall survival (OS) and LNR, node (N) status, and histopathologic status were evaluated. The 5-year survival rate was 42.5% among all patients and 26.6% for patients aged 65 years or older. In the multivariate analysis, age ≥65 years, advanced-stage disease, non-squamous cell carcinomas, pN status, and having multiple-station pN2 and multiple-station pN1 disease were found to be poor prognostic factors (p 
ISSN:0001-5458
2577-0160
DOI:10.1080/00015458.2021.1932181