Effect of mood on long-term disability in younger stroke survivors: results from the Psychosocial Outcomes In StrokE (POISE) study

Anxiety and depression are common among stroke survivors, and their effect on long-term outcome remains unknown in those under 65 years of age. We investigated the association between early anxiety/depression after stroke and 12-month disability, and whether this is modified by sex. The Psychosocial...

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Published in:Topics in stroke rehabilitation 2022-05, Vol.29 (4), p.286-294
Main Authors: Liang, C, Van Laar Veth, AJ, Li, Q, Zheng, D, Hackett, ML
Format: Article
Language:English
Subjects:
Anxiety
Anxiety - epidemiology
Anxiety - etiology
depression
Depression - epidemiology
Depression - etiology
disability
Disability Evaluation
function
HADS
Humans
POISE
Prospective Studies
stroke
Stroke - complications
Stroke - epidemiology
Stroke - therapy
Survivors - psychology
WHODAS-II
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cited_by cdi_FETCH-LOGICAL-c413t-ed9a2eaad31e956527027205be414de713f8a5d50ae45f88163b93a3cbac25c13
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container_issue 4
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container_title Topics in stroke rehabilitation
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creator Liang, C
Van Laar Veth, AJ
Li, Q
Zheng, D
Hackett, ML
description Anxiety and depression are common among stroke survivors, and their effect on long-term outcome remains unknown in those under 65 years of age. We investigated the association between early anxiety/depression after stroke and 12-month disability, and whether this is modified by sex. The Psychosocial Outcomes In StrokE (POISE) study was a prospective observational cohort study that recruited 441 younger (< 65 years) stroke survivors ≤28 days of acute stroke. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale, and disability using the World Health Organization Disability Assessment Scale version II (WHODAS-II). Associations between baseline anxiety/depression, and disability at 12-months was tested using analysis of covariance. Subgroup analysis was conducted using interaction term. 92 (25%) had anxiety and 53 (14%) depression at baseline. Multivariable models showed significant association between baseline anxiety and 12-month disability (WHODAS-II score 15.24 vs. 11.49, p
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We investigated the association between early anxiety/depression after stroke and 12-month disability, and whether this is modified by sex. The Psychosocial Outcomes In StrokE (POISE) study was a prospective observational cohort study that recruited 441 younger (&lt; 65 years) stroke survivors ≤28 days of acute stroke. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale, and disability using the World Health Organization Disability Assessment Scale version II (WHODAS-II). Associations between baseline anxiety/depression, and disability at 12-months was tested using analysis of covariance. Subgroup analysis was conducted using interaction term. 92 (25%) had anxiety and 53 (14%) depression at baseline. Multivariable models showed significant association between baseline anxiety and 12-month disability (WHODAS-II score 15.24 vs. 11.49, p &lt; .05). Those with anxiety had more impairment in 'cognition' (WHODAS-II score 18.26 vs. 8.71, p &lt; .001), 'getting along' (WHODAS-II score 11.87 vs. 7.42, p &lt; .05) and 'participation' (WHODAS-II score 22.37 vs. 15.92, p &lt; .005) WHODAS-II. No significant relationship was found between baseline depression and long-term disability. There was no differential effect of anxiety by sex found in this study. 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Those with anxiety had more impairment in 'cognition' (WHODAS-II score 18.26 vs. 8.71, p &lt; .001), 'getting along' (WHODAS-II score 11.87 vs. 7.42, p &lt; .05) and 'participation' (WHODAS-II score 22.37 vs. 15.92, p &lt; .005) WHODAS-II. No significant relationship was found between baseline depression and long-term disability. There was no differential effect of anxiety by sex found in this study. 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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Anxiety
Anxiety - epidemiology
Anxiety - etiology
depression
Depression - epidemiology
Depression - etiology
disability
Disability Evaluation
function
HADS
Humans
POISE
Prospective Studies
stroke
Stroke - complications
Stroke - epidemiology
Stroke - therapy
Survivors - psychology
WHODAS-II
title Effect of mood on long-term disability in younger stroke survivors: results from the Psychosocial Outcomes In StrokE (POISE) study
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