miR-29a/b 1 Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation

was reportedly involved in the regulation of the reproductive function in female mice, but the underlying molecular mechanisms are not clear. In this study, female mice lacking showed a delay in vaginal opening, irregular estrous cycles, ovulation disorder and subfertility. The level of luteinizing...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2021, Vol.12, p.636220
Main Authors: Guo, Yang, Wu, Youbing, Shi, Jiahao, Zhuang, Hua, Ci, Lei, Huang, Qin, Wan, Zhipeng, Yang, Hua, Zhang, Mengjie, Tan, Yutong, Sun, Ruilin, Xu, Leon, Wang, Zhugang, Shen, Ruling, Fei, Jian
Format: Article
Language:English
Subjects:
Animals
Exocytosis
Female
Fertility
Gene Expression Regulation
Gonadotropin-Releasing Hormone - metabolism
Heterozygote
Humans
Luteinizing Hormone - metabolism
Male
Mice
Mice, Knockout
MicroRNAs - genetics
MicroRNAs - metabolism
Oocytes - metabolism
Ovary - physiology
Ovulation
Phenotype
Pituitary Gland
Progesterone - blood
Superovulation
Tandem Mass Spectrometry
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Summary:was reportedly involved in the regulation of the reproductive function in female mice, but the underlying molecular mechanisms are not clear. In this study, female mice lacking showed a delay in vaginal opening, irregular estrous cycles, ovulation disorder and subfertility. The level of luteinizing hormone (LH) was significantly lower in plasma but higher in pituitary of mutant mice. However, egg development was normal in mutant mice and the ovulation disorder could be rescued by the superovulation treatment. These results suggested that the LH secretion was impaired in mutant mice. Further studies showed that deficiency of in mice resulted in an abnormal expression of a number of proteins involved in vesicular transport and exocytosis in the pituitary, indicating the mutant mice had insufficient LH secretion. However, the detailed mechanism needs more research.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2021.636220