Protective effect of Phaeoporus obliquus polysaccharide against acute liver injury induced by carbon tetrachloride and alcohol in mice

Studied the optimum extraction process of polysaccharide from Phaeoporus obliquus and the effect of Phaeoporus obliquus polysaccharide on carbon tetrachloride (CCl )- or alcohol-induced acute liver injury in mice. The main factor in influencing the extraction rate of Phaeoporus obliquus polysacchari...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2021-03, Vol.34 (2), p.649
Main Authors: Lei, Zhang, Xiao-Hong, Ren, Jing, He, Wan-Nan, Li, Jing-Wei, Hao, Yun-Rong, Jing, Jun-Rong, Chai, Xiao-Wei, Sun, Chun-Lei, Wan
Format: Article
Language:English
Subjects:
Alanine Transaminase - drug effects
Alanine Transaminase - metabolism
Alkaline Phosphatase - drug effects
Alkaline Phosphatase - metabolism
Animals
Aspartate Aminotransferases - drug effects
Aspartate Aminotransferases - metabolism
Carbon Tetrachloride - toxicity
Central Nervous System Depressants - toxicity
Chemical and Drug Induced Liver Injury - metabolism
Cytochrome P-450 CYP2E1 - drug effects
Cytochrome P-450 CYP2E1 - genetics
Ethanol - toxicity
Fungal Polysaccharides - pharmacology
Hepatocytes - drug effects
Hepatocytes - metabolism
Hepatocytes - pathology
Inonotus
Liver - drug effects
Liver - metabolism
Liver - pathology
Liver Diseases, Alcoholic - metabolism
Malondialdehyde - metabolism
Mice
RNA, Messenger - drug effects
RNA, Messenger - metabolism
Superoxide Dismutase - drug effects
Superoxide Dismutase - metabolism
Tumor Necrosis Factor-alpha - drug effects
Tumor Necrosis Factor-alpha - metabolism
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Summary:Studied the optimum extraction process of polysaccharide from Phaeoporus obliquus and the effect of Phaeoporus obliquus polysaccharide on carbon tetrachloride (CCl )- or alcohol-induced acute liver injury in mice. The main factor in influencing the extraction rate of Phaeoporus obliquus polysaccharide were extraction power and time, which was a kind of pyran glucose by infrared spectroscopy. CCl and alcohol were employed respectively to establish CCl4 and alcohol-induced acute liver injury mouse models. Compared with model groups mice, Phaeoporus obliquus polysaccharide treatment at the doses of 100mg/kg and 200mg/kg exhibited an obvious reduction liver index, ALP, ALT, AST levels, MDA content and TNF-α level (p
ISSN:1011-601X
DOI:10.36721/PJPS.2021.34.2.REG.649-656.1