Cancer cell membrane-coated nanogels as a redox/pH dual-responsive drug carrier for tumor-targeted therapy

Nanocarriers have shown great advantages in increasing the efficiency of drug delivery and reducing drug side effects. However, their lack of targeting and on-demand drug release abilities will seriously limit their clinical application. Herein, we report tumor cell membrane coated nanogels (NGs) wi...

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Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2021-10, Vol.9 (38), p.831-837
Main Authors: Xu, Weide, Wang, Jilong, Li, Qinghua, Wu, Chenghu, Wu, Lingling, Li, Kaiqiang, Li, Qin, Han, Qing, Zhu, Jingjing, Bai, Yongheng, Deng, Junjie, Lyu, Jianxin, Wang, Zhen
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - metabolism
Antibiotics, Antineoplastic - pharmacology
Cell Line, Tumor
Cell Membrane - chemistry
Cell membranes
Cell Proliferation - drug effects
Chemotherapy
Coatings
Doxorubicin - chemistry
Doxorubicin - metabolism
Doxorubicin - pharmacology
Drug carriers
Drug Carriers - chemistry
Drug delivery
Drug Liberation
Female
Glutathione - chemistry
Hydrogen-Ion Concentration
In vivo methods and tests
Mice
Mice, Inbred BALB C
Nanogels - chemistry
Neoplasms - drug therapy
Oxidation-Reduction
pH effects
Polydispersity
Side effects
Tumors
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Summary:Nanocarriers have shown great advantages in increasing the efficiency of drug delivery and reducing drug side effects. However, their lack of targeting and on-demand drug release abilities will seriously limit their clinical application. Herein, we report tumor cell membrane coated nanogels (NGs) with redox/pH dual-responsive behavior for enhanced tumor chemotherapy. The cell membrane coating improves the tumor targeting efficiency, and stimuli-responsive drug release enhances the therapeutic effects. These NGs are well dispersed in PBS with an average size of 109.1 ± 5.2 nm and a narrow polydispersity index of 0.12. Both in vitro and in vivo studies indicate that these NGs can responsively release the therapeutic drug DOX under acidic conditions or high GSH concentrations and effectively inhibit tumor growth. Based on the results, this nanogel shows promise as a platform for tumor-targeted chemotherapy for future clinical translation. Redox/pH dual-responsive nanogels have shown great advantages in enhancing tumor chemotherapy.
ISSN:2050-750X
2050-7518
DOI:10.1039/d1tb00788b