Ultra-high photoactive thiadiazolo[3,4-]quinoxaline nanoparticles with active-targeting capability for deep photodynamic therapy

Improving the effective treatment depth of photodynamic therapy (PDT) is an important issue to resolve for its clinical application. In this study, a new biocompatible photosensitizer (PS), namely TQs-PEG4, based on thiadiazolo[3,4- g ]quinoxaline (TQ) with ultra-high photoactive property is designe...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2021-10, Vol.9 (39), p.833-834
Main Authors: Zhang, Li-Peng, Li, Xianqiang, Zhao, Hongyou, Kang, Lin, Liu, Shiyang, Liu, Tianlong, Zhao, Yuxia
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biodegradability
Biodegradation
Breast Neoplasms
Cell Line, Tumor
Cell Survival - drug effects
Copolymers
Drug Delivery Systems
Drug Design
Female
Humans
Irradiation
Mice
Mice, Nude
Molecular Structure
Nanoparticles
Nanoparticles - chemistry
Neoplasms, Experimental
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - chemical synthesis
Photosensitizing Agents - pharmacology
Pork
Quinoxaline
Quinoxalines
Quinoxalines - chemistry
Singlet oxygen
Tumor cell lines
Tumors
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Summary:Improving the effective treatment depth of photodynamic therapy (PDT) is an important issue to resolve for its clinical application. In this study, a new biocompatible photosensitizer (PS), namely TQs-PEG4, based on thiadiazolo[3,4- g ]quinoxaline (TQ) with ultra-high photoactive property is designed and synthesized. TQs-PEG4 possesses an ultra-high singlet oxygen quantum yield ( Φ Δ = 1.04). After encapsulating it with a biodegradable copolymer (DSPE-mPEG2000-cRGD), well distributed organic TQs-PEG4 nanoparticles (NPs) are formed with good water dispersity and excellent active tumor-targeting property. In vitro PDT experiments reveal that TQs-PEG4 NPs present excellent phototoxicities towards different cancer cell lines with an ultra-low dosage (
ISSN:2050-750X
2050-7518
DOI:10.1039/d1tb01306h