Overview of Nonhuman Primate Models of SARS-CoV-2 Infection

COVID-19, the disease caused by the SARS-CoV-2 betacoronavirus, was declared a pandemic by the World Health Organization on March 11, 2020. Since then, SARS-CoV-2 has triggered a devastating global health and economic emergency. In response, a broad range of preclinical animal models have been used...

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Bibliographic Details
Published in:Comparative medicine 2021-10, Vol.71 (5), p.411-432
Main Author: Trichel, Anita M
Format: Article
Language:English
Subjects:
Animals
COVID-19
COVID-19 Vaccines
Humans
Pandemics
Primates
SARS-CoV-2
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Summary:COVID-19, the disease caused by the SARS-CoV-2 betacoronavirus, was declared a pandemic by the World Health Organization on March 11, 2020. Since then, SARS-CoV-2 has triggered a devastating global health and economic emergency. In response, a broad range of preclinical animal models have been used to identify effective therapies and vaccines. Current animal models do not express the full spectrum of human COVID-19 disease and pathology, with most exhibiting mild to moderate disease without mortality. NHPs are physiologically, genetically, and immunologically more closely related to humans than other animal species; thus, they provide a relevant model for SARS-CoV-2 investigations. This overview summarizes NHP models of SARS-CoV-2 and their role in vaccine and therapeutic development.
ISSN:1532-0820
2769-819X
DOI:10.30802/AALAS-CM-20-000119