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Overview of Nonhuman Primate Models of SARS-CoV-2 Infection
COVID-19, the disease caused by the SARS-CoV-2 betacoronavirus, was declared a pandemic by the World Health Organization on March 11, 2020. Since then, SARS-CoV-2 has triggered a devastating global health and economic emergency. In response, a broad range of preclinical animal models have been used...
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| Published in: | Comparative medicine 2021-10, Vol.71 (5), p.411-432 |
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| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c479t-9a23759e7c8f73e0b952e28063e8a1f0e0ce06a780afdac63472441593b3f0b93 |
| container_end_page | 432 |
| container_issue | 5 |
| container_start_page | 411 |
| container_title | Comparative medicine |
| container_volume | 71 |
| creator | Trichel, Anita M |
| description | COVID-19, the disease caused by the SARS-CoV-2 betacoronavirus, was declared a pandemic by the World Health Organization on March 11, 2020. Since then, SARS-CoV-2 has triggered a devastating global health and economic emergency. In response, a broad range of preclinical animal models
have been used to identify effective therapies and vaccines. Current animal models do not express the full spectrum of human COVID-19 disease and pathology, with most exhibiting mild to moderate disease without mortality. NHPs are physiologically, genetically, and immunologically more closely
related to humans than other animal species; thus, they provide a relevant model for SARS-CoV-2 investigations. This overview summarizes NHP models of SARS-CoV-2 and their role in vaccine and therapeutic development. |
| doi_str_mv | 10.30802/AALAS-CM-20-000119 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 1532-0820 |
| ispartof | Comparative medicine, 2021-10, Vol.71 (5), p.411-432 |
| issn | 1532-0820 2769-819X |
| language | eng |
| recordid | cdi_pubmed_primary_34548126 |
| source | Open Access: PubMed Central; IngentaConnect Journals |
| subjects | Animals COVID-19 COVID-19 Vaccines Humans Pandemics Primates SARS-CoV-2 |
| title | Overview of Nonhuman Primate Models of SARS-CoV-2 Infection |
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