Prediction of Absorbed Dose to Normal Organs with Endocrine Tumors for I-131 by use of 99m TC Single Photon Emission Computed Tomography/Computed Tomography and Geant4 Application for Tomographic Emission Simulation

• Published in: Indian journal of nuclear medicine 2021-07, Vol.36 (3), p.273
• Main Authors: Asl, Rohollah Ghahraman, Sabbaghi, Rezvan, Ahangari, Hadi Taleshi, Hejazi, Payman, Foroutan, Majid
• Format: Article
• Language: English
• ISSN: 0972-3919
• DOI: 10.4103/ijnm.ijnm_6_21

This study aimed to predict the dose absorbed by normal organs with neuroendocrine tumors for I using single photon emission computed tomography/computed tomography (SPECT/CT) images and Geant4 application for tomographic emission (GATE) simulation. Four to 5 whole-body planar scan series, along with one SPECT/CT image, were taken from four patients following Tc-hynic-Tyr -octreotide radiotracer injection. After image quantification, the residence time of each organ was calculated using the image analysis and the activity time curves. The energy deposit and dose conversion (S-value) were extracted from the GATE simulation for the target organs of each patient. Using the residence times and S-values, the mean absorbed dose for the target organs of each patient was calculated and compared with the data obtained from the standard method. Very close agreement was obtained between the S-value of the self-organ irradiation. The mean percentage difference between the two methods (i.e. GATE and Medical Internal Radiation Dose [MIRD]) was 1.8%, while a weak agreement was observed for cross-organ irradiation. The percentage difference between the total absorbed doses by the organs was 2%. The percentage difference between the absorbed doses obtained for tumors and three considered normal organs estimated by the GATE method was slightly higher than the MIRD method (about 11% on average for tumors). Regardless of the small difference between the obtained results for the organs and absorbed doses of the tumors in the present study, patient-specific dosimetry by the GATE methods is useful and essential for therapeutic radionuclides such as I due to high cross-dose effects, especially for young adult patients, to ensure the radiation safety and increase the effectiveness of the treatment.