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Cytogenetic Analysis of a Gossypol-Induced Murine Myxosarcoma

Cytogenetic analysis of gossypol acetate-induced murine myxosarcoma demonstrated a stemline of 78 chromosomes and the presence of three marker (M) chromosomes produced by robertsonian translocation. Tumor cells at passage 1 that contain chromosomes M1 and M2 were nontumorigenic, whereas cells at pas...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1987-06, Vol.78 (6), p.1203-1209
Main Authors: Dhaliwal, Manjeet K., Norman, James O., Pathak, Sen, Busbee, David L.
Format: Article
Language:English
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Summary:Cytogenetic analysis of gossypol acetate-induced murine myxosarcoma demonstrated a stemline of 78 chromosomes and the presence of three marker (M) chromosomes produced by robertsonian translocation. Tumor cells at passage 1 that contain chromosomes M1 and M2 were nontumorigenic, whereas cells at passage 3 were tumorigenic in syngeneic mice and showed M1, M2, and M3. The presence of M3 has been implicated to be responsible for the tumorigenic phenotype.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/78.6.1203