Causes of gastrointestinal bleeding in oral anticoagulant users compared to non-users in a population-based study

Causes of gastrointestinal bleeding (GIB) in patients on oral anticoagulants (OACs) are not well established. The aims of the study were to compare the causes of GIB in patients on OACs and those not on OAC therapy. A nationwide study of all GIB events in patients on OACs in Iceland from 2014-2019 w...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 2022-02, Vol.57 (2), p.239-245
Main Authors: Ágústsson, Arnar S., Ingason, Arnar B., Rumba, Edward, Pálsson, Daníel, Reynisson, Indriði E., Hreinsson, Jóhann P., Björnsson, Einar S.
Format: Article
Language:English
Subjects:
Administration, Oral
Angiodysplasia - complications
Anticoagulants - adverse effects
anticoagulation
Atrial Fibrillation - drug therapy
atrial-fibrillation
changing trends
colitis
colon cancer
colorectal-cancer
epidemiology
etiology
Gastroenterologi
Gastroenterology & Hepatology
Gastroenterology and Hepatology
Gastrointestinal bleeding
Gastrointestinal Hemorrhage - chemically induced
Gastrointestinal Hemorrhage - epidemiology
hemorrhage
Humans
ischemic
ischemic colitis
mortality
nationwide
risk
Risk Factors
warfarin
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Summary:Causes of gastrointestinal bleeding (GIB) in patients on oral anticoagulants (OACs) are not well established. The aims of the study were to compare the causes of GIB in patients on OACs and those not on OAC therapy. A nationwide study of all GIB events in patients on OACs in Iceland from 2014-2019 was conducted. Bleeding events were obtained through ICD-10 codes and review of endoscopy databases, confirmed by review of medical records. For comparison, patients not on OACs from previous Icelandic population-based studies were used. Among 752 GIB events in 12,005 patients on OACs, 273 (1.9%) had verified upper and 391 (2.7%) had verified lower GIB. For lower GIB, multivariate analysis showed that OAC users were more likely to have colonic polyps (OR 6.6, 95% CI: 2.4 − 17.8, p 
ISSN:0036-5521
1502-7708
DOI:10.1080/00365521.2021.1998600