Synthesis of taurine-Cu 3 (PO 4 ) 2 hybrid nanoflower and their peroxidase-mimic and antimicrobial properties

Herein, we report the synthesis of taurine incorporated (sulfur containing organic molecule derived from methionine and cysteine) hybrid nanoflowers (thNFs) with an intrinsic peroxidase-mimic and antimicrobial activities in the presence of H O . Formation of thNFs using non-enzyme molecules was for...

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Bibliographic Details
Published in:Journal of biotechnology 2022-01, Vol.343, p.96
Main Authors: Yilmaz, Sevim Gokce, Demirbas, Ayse, Karaagac, Zehra, Dadi, Seyma, Celik, Cagla, Yusufbeyoglu, Sadi, Ildiz, Nilay, Mandal, Amit Kumar, Cimen, Behzat, Ocsoy, Ismail
Format: Article
Language:English
Subjects:
Anti-Infective Agents - pharmacology
Copper
Escherichia coli
Hydrogen Peroxide
Nanostructures
Peroxidase
Staphylococcus aureus
Taurine
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Summary:Herein, we report the synthesis of taurine incorporated (sulfur containing organic molecule derived from methionine and cysteine) hybrid nanoflowers (thNFs) with an intrinsic peroxidase-mimic and antimicrobial activities in the presence of H O . Formation of thNFs using non-enzyme molecules was for the first time and systematically studied as a function of the taurine concentration, types of metal ions (Cu , Fe and Fe ) and pH values of reaction solution. The peroxidase like activities of thNFs rely on Fenton-like reaction against guaiacol used as a model substrate. The efficiency of Fenton reaction can be attributed to porous structure and presence of ions of transition elements in the thNFs. The thNFs were further characterized using FTIR, XRD, SEM and EDX. The thNFs also showed remarkable antimicrobial properties against S. aureus, E. coli, B. cereus and C. albicans. We claim that nonprotein-based NFs can be considered as new generation nano-biocatalysts as an alternative to enzymes and can be used in various medicinal, biochemical, immunological, biotechnological, and industrial applications.
ISSN:1873-4863