A new anti-proliferative compound from an endophytic fungus, Phoma sp

A new oxazole-type compound (1), named macrooxazole E, and three known macrooxazoles A-C (2-4), were isolated from ethyl acetate (EtOAc) extracts of Phoma sp. JS0228 cultures, an endophytic fungus of Morus alba (M. alba). Structures of the isolated compounds were determined using spectroscopic metho...

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Bibliographic Details
Published in:Natural product research 2022-11, Vol.36 (21), p.5584-5590
Main Authors: Ku, Hyeri, Baek, Ji-Yun, Kang, Ki Sung, Shim, Sang Hee
Format: Article
Language:English
Subjects:
Acetic acid
Antiproliferatives
Breast cancer
Carboxylic acids
endophyte
Endophytes
Ethyl acetate
Fungi
macrooxazole
Mass spectrometry
Mass spectroscopy
NMR
Nuclear magnetic resonance
Oxazole
Phoma
Phoma sp
Prostate cancer
structure elucidation
Tumor cell lines
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Summary:A new oxazole-type compound (1), named macrooxazole E, and three known macrooxazoles A-C (2-4), were isolated from ethyl acetate (EtOAc) extracts of Phoma sp. JS0228 cultures, an endophytic fungus of Morus alba (M. alba). Structures of the isolated compounds were determined using spectroscopic methods, such as 1 D- and 2 D-nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS). Macrooxazole E (1) differed from macrooxazole C only in the presence of methyl carboxylate instead of free carboxylic acid. Macrooxazole C showed moderate anti-proliferative activities against human breast cancer (MCF-7) and prostate cancer (LNCaP) cell lines with IC 50 values of 0.29 mM and 0.36 mM, respectively. This study presents the possibility of the endophytic fungus Phoma sp. JS0228 to produce new bioactive natural compounds.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.2022663