Allogeneic H-2 Antigen Expression is Insufficient for Tumor Rejection

Murine A strain (KkDdLd) sarcoma I (SaI) tumor cells have been transfected with a cloned H-2Kb gene. The resulting clones (SKB clones) stably express high levels of a molecule that is serologically and biochemically indistinguishable from the H-2Kb antigen. SKB clones are not susceptible to cytotoxi...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1987-12, Vol.84 (23), p.8613-8617
Main Authors: Cole, Geoffrey A., Cole, Gerald A., Clements, Virginia K., Garcia, Elizabeth P., Ostrand-Rosenberg, Suzanne
Format: Article
Language:English
Subjects:
Animals
Antigens
Biological and medical sciences
Cell lines
Cytotoxicity, Immunologic
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft Rejection
H-2 Antigens - genetics
H-2 Antigens - immunology
Histocompatibility antigens class I
Mice
Molecules
Sarcoma
Sarcoma, Experimental - immunology
Spleen cells
T lymphocytes
T-Lymphocytes, Cytotoxic - immunology
Tissue, organ and graft immunology
Transfection
Tumor cell line
Tumor Cells, Cultured
Tumors
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Summary:Murine A strain (KkDdLd) sarcoma I (SaI) tumor cells have been transfected with a cloned H-2Kb gene. The resulting clones (SKB clones) stably express high levels of a molecule that is serologically and biochemically indistinguishable from the H-2Kb antigen. SKB clones are not susceptible to cytotoxic T lymphocyte-mediated lysis by H-2Kb-specific bulk, cloned, or H-2Kb-restricted lymphocytic choriomeningitis virus-specific effectors. Survival times of A/J and B10.A mice challenged i.p. with the H-2Kb-expressing transfectants and the parental SaI cells are similar, suggesting that the presence of an allogeneic major histocompatibility complex class I antigen on the surface of this tumor line is insufficient for tumor rejection.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.84.23.8613