H 2 S donating corticosteroids: Design, synthesis and biological evaluation in a murine model of asthma

• Published in: Journal of advanced research 2022-01, Vol.35, p.267
• Main Authors: Corvino, Angela, Citi, Valentina, Fiorino, Ferdinando, Frecentese, Francesco, Magli, Elisa, Perissutti, Elisa, Santagada, Vincenzo, Calderone, Vincenzo, Martelli, Alma, Gorica, Era, Brogi, Simone, Colombo, Flavia Faganello, Capello, Caroline Nunes, Araujo Ferreira, Heloisa Helena, Rimoli, Maria Grazia, Sodano, Federica, Rolando, Barbara, Pavese, Francesca, Petti, Antonio, Muscará, Marcelo Nicolás, Caliendo, Giuseppe, Severino, Beatrice
• Format: Article
• Language: English
• Subjects: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Asthma - drug therapy; Disease Models, Animal; Humans; Hydrogen Sulfide; Mice
• ISSN: 2090-1224
• DOI: 10.1016/j.jare.2021.05.008

Hydrogen sulfide (H S) is a fundamental biological endogenous gas-mediator in the respiratory system. It regulates pivotal patho-physiological processes such as oxidative stress, pulmonary circulation, airway tone and inflammation. We herein describe the design and synthesis of molecular hybrids obtained by the condensation of several corticosteroids with different hydrogen sulfide releasing moieties. All the molecules are characterized for their ability to release H S both via amperometric approach and using a fluorescent probe. The chemical stability of the newly synthesized hybrid molecules has been investigated at differing pH values and in human serum. Prednisone-TBZ hybrid (compound ) was selected for further evaluations. The obtained results from the and studies clearly show evidence in favor of the anti-inflammatory properties of the released H S. The protective effect on airway remodeling makes the hybrid Prednisone-TBZ (compound ) as a promising therapeutic option in reducing allergic asthma symptoms and exacerbations.