Two Cases of Acute Macular Neuroretinopathy Associated with the Adenovirus-based COVID-19 Vaccine Vaxzevria (Astrazeneca)

To report two cases of acute macular neuroretinopathy (AMN) in young female patients following the administration of the adenovirus-based coronavirus disease 2019 (COVID-19) vaccine Vaxzevria (AstraZeneca). Spectral-domain optical coherence tomography and infrared imaging were used to confirm the di...

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Bibliographic Details
Published in:Ocular immunology and inflammation 2022-07, Vol.30 (5), p.1234-1239
Main Authors: Franchi, Alexander, Rauchegger, Teresa, Palme, Christoph, Frede, Katharina, Haas, Gertrud, Blatsios, Georgios, Kralinger, Martina, Zehetner, Claus
Format: Article
Language:English
Subjects:
Acute macular neuroretinopathy
COVID-19
SARS-CoV-2
vaccination
vaxzevria
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Summary:To report two cases of acute macular neuroretinopathy (AMN) in young female patients following the administration of the adenovirus-based coronavirus disease 2019 (COVID-19) vaccine Vaxzevria (AstraZeneca). Spectral-domain optical coherence tomography and infrared imaging were used to confirm the diagnosis of AMN. Both patients showed a parafoveal hyperreflective band in the outer nuclear layer, disruption of the ellipsoid and interdigitation zones of the photoreceptor layers, and correlating hyporeflective areas on the near-infrared images. Both patients presented with flu-like fever and sudden onset of fortifications within 48 hours of vaccination. One patient showed altered flow in the deep capillary plexus and highly elevated thrombotic parameters. We report a possible association between immune-mediated AMN and the administration of adenovirus-based COVID-19 vaccine Vaxzevria.
ISSN:0927-3948
1744-5078
DOI:10.1080/09273948.2022.2027463