The effect of prophylactic use of tranexamic acid for cesarean section

Treatment with tranexamic acid (TxA) significantly reduces maternal death due to postpartum hemorrhage. There is increasing interest in whether it can also be used as prophylaxis for postpartum hemorrhage, especially during cesarean sections (CS). This impact study is aimed to determine the effect o...

Full description

Saved in:
Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2022-12, Vol.35 (25), p.9157-9162
Main Authors: Binyamin, Yair, Orbach-Zinger, Sharon, Gruzman, Igor, Frenkel, Amit, Lerman, Sofia, Zlotnik, Alexander, Frank, Dmitry, Ioscovich, Alexander, Erez, Offer, Heesen, Michael
Format: Article
Language:English
Subjects:
cesarean section
hemoglobin
post-partum hemorrhage
prophylaxis
renal failure
Tranexamic acid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c366t-67640a951b837cc4a95fa8ed2c87d493b7483aa2872405fd284a3dd7211a273f3
cites cdi_FETCH-LOGICAL-c366t-67640a951b837cc4a95fa8ed2c87d493b7483aa2872405fd284a3dd7211a273f3
container_end_page 9162
container_issue 25
container_start_page 9157
container_title The journal of maternal-fetal & neonatal medicine
container_volume 35
creator Binyamin, Yair
Orbach-Zinger, Sharon
Gruzman, Igor
Frenkel, Amit
Lerman, Sofia
Zlotnik, Alexander
Frank, Dmitry
Ioscovich, Alexander
Erez, Offer
Heesen, Michael
description Treatment with tranexamic acid (TxA) significantly reduces maternal death due to postpartum hemorrhage. There is increasing interest in whether it can also be used as prophylaxis for postpartum hemorrhage, especially during cesarean sections (CS). This impact study is aimed to determine the effect of routine prophylactic tranexamic acid during CS on maternal hemorrhage and the rate of the associated side effects. This retrospective population-based cohort single-center impact study include 2000 women who delivered by CS divided into two groups with (n = 1000) and without (n = 1000) prophylactic administration of 1gram TxA prior to surgery. Primary outcomes were to determine the: (1) rate of women experiencing >10% or ≥2 g/dL hemoglobin drop from the preoperative concentration within 24 h after CS. (2) incidence of women having a hemoglobin drop of ≥2 g/dL. Women who did not receive TxA prophylactic had a higher rate of >10% hemoglobin decrease and a higher rate of ≥2 g/dL hemoglobin decrease Than those who received TxA prophylaxis (p 
doi_str_mv 10.1080/14767058.2021.2019215
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_35068314</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2622480372</sourcerecordid><originalsourceid>FETCH-LOGICAL-c366t-67640a951b837cc4a95fa8ed2c87d493b7483aa2872405fd284a3dd7211a273f3</originalsourceid><addsrcrecordid>eNp9kEtPwzAQhC0EoqXwE0A5cknxK7F7A1UUkCpxKWdr64calMTFTgT99zhqypGLdzWa8Y4-hG4JnhMs8QPhohS4kHOKKUkPWVBSnKHpoOd8UfDzcR9ME3QV4ydOTo6LSzRhBS4lI3yKVpudzaxzVneZd9k--P3uUIPuKp310Q5aF6C1P9AkBXRlMudDpm2EYKHNYgpWvr1GFw7qaG_GOUMfq-fN8jVfv7-8LZ_WuWZl2eWlKDmGRUG2kgmteVodSGuolsLwBdsKLhkAlYKmos5QyYEZIyghQAVzbIbuj_-mol-9jZ1qqqhtXaeKvo-KlpRyiZmgyVocrTr4GIN1ah-qBsJBEawGhOqEUA0I1Ygw5e7GE_22seYvdWKWDI9HQ9UmFA18-1Ab1cGh9sElVrqKiv1_4xfeB37E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2622480372</pqid></control><display><type>article</type><title>The effect of prophylactic use of tranexamic acid for cesarean section</title><source>Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)</source><creator>Binyamin, Yair ; Orbach-Zinger, Sharon ; Gruzman, Igor ; Frenkel, Amit ; Lerman, Sofia ; Zlotnik, Alexander ; Frank, Dmitry ; Ioscovich, Alexander ; Erez, Offer ; Heesen, Michael</creator><creatorcontrib>Binyamin, Yair ; Orbach-Zinger, Sharon ; Gruzman, Igor ; Frenkel, Amit ; Lerman, Sofia ; Zlotnik, Alexander ; Frank, Dmitry ; Ioscovich, Alexander ; Erez, Offer ; Heesen, Michael</creatorcontrib><description>Treatment with tranexamic acid (TxA) significantly reduces maternal death due to postpartum hemorrhage. There is increasing interest in whether it can also be used as prophylaxis for postpartum hemorrhage, especially during cesarean sections (CS). This impact study is aimed to determine the effect of routine prophylactic tranexamic acid during CS on maternal hemorrhage and the rate of the associated side effects. This retrospective population-based cohort single-center impact study include 2000 women who delivered by CS divided into two groups with (n = 1000) and without (n = 1000) prophylactic administration of 1gram TxA prior to surgery. Primary outcomes were to determine the: (1) rate of women experiencing &gt;10% or ≥2 g/dL hemoglobin drop from the preoperative concentration within 24 h after CS. (2) incidence of women having a hemoglobin drop of ≥2 g/dL. Women who did not receive TxA prophylactic had a higher rate of &gt;10% hemoglobin decrease and a higher rate of ≥2 g/dL hemoglobin decrease Than those who received TxA prophylaxis (p &lt; .0001, for both). Mean hospital stay (p = .002) and umbilical cord pH (p &lt; .05) were higher among those who received TxA prophylaxis than in those who were not treated. The finding of our study suggest that prophylactic administration of TxA prior to CS improves maternal and neonatal outcomes.</description><identifier>ISSN: 1476-7058</identifier><identifier>EISSN: 1476-4954</identifier><identifier>DOI: 10.1080/14767058.2021.2019215</identifier><identifier>PMID: 35068314</identifier><language>eng</language><publisher>England: Taylor &amp; Francis</publisher><subject>cesarean section ; hemoglobin ; post-partum hemorrhage ; prophylaxis ; renal failure ; Tranexamic acid</subject><ispartof>The journal of maternal-fetal &amp; neonatal medicine, 2022-12, Vol.35 (25), p.9157-9162</ispartof><rights>2022 Informa UK Limited, trading as Taylor &amp; Francis Group 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-67640a951b837cc4a95fa8ed2c87d493b7483aa2872405fd284a3dd7211a273f3</citedby><cites>FETCH-LOGICAL-c366t-67640a951b837cc4a95fa8ed2c87d493b7483aa2872405fd284a3dd7211a273f3</cites><orcidid>0000-0003-2147-7353</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35068314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Binyamin, Yair</creatorcontrib><creatorcontrib>Orbach-Zinger, Sharon</creatorcontrib><creatorcontrib>Gruzman, Igor</creatorcontrib><creatorcontrib>Frenkel, Amit</creatorcontrib><creatorcontrib>Lerman, Sofia</creatorcontrib><creatorcontrib>Zlotnik, Alexander</creatorcontrib><creatorcontrib>Frank, Dmitry</creatorcontrib><creatorcontrib>Ioscovich, Alexander</creatorcontrib><creatorcontrib>Erez, Offer</creatorcontrib><creatorcontrib>Heesen, Michael</creatorcontrib><title>The effect of prophylactic use of tranexamic acid for cesarean section</title><title>The journal of maternal-fetal &amp; neonatal medicine</title><addtitle>J Matern Fetal Neonatal Med</addtitle><description>Treatment with tranexamic acid (TxA) significantly reduces maternal death due to postpartum hemorrhage. There is increasing interest in whether it can also be used as prophylaxis for postpartum hemorrhage, especially during cesarean sections (CS). This impact study is aimed to determine the effect of routine prophylactic tranexamic acid during CS on maternal hemorrhage and the rate of the associated side effects. This retrospective population-based cohort single-center impact study include 2000 women who delivered by CS divided into two groups with (n = 1000) and without (n = 1000) prophylactic administration of 1gram TxA prior to surgery. Primary outcomes were to determine the: (1) rate of women experiencing &gt;10% or ≥2 g/dL hemoglobin drop from the preoperative concentration within 24 h after CS. (2) incidence of women having a hemoglobin drop of ≥2 g/dL. Women who did not receive TxA prophylactic had a higher rate of &gt;10% hemoglobin decrease and a higher rate of ≥2 g/dL hemoglobin decrease Than those who received TxA prophylaxis (p &lt; .0001, for both). Mean hospital stay (p = .002) and umbilical cord pH (p &lt; .05) were higher among those who received TxA prophylaxis than in those who were not treated. The finding of our study suggest that prophylactic administration of TxA prior to CS improves maternal and neonatal outcomes.</description><subject>cesarean section</subject><subject>hemoglobin</subject><subject>post-partum hemorrhage</subject><subject>prophylaxis</subject><subject>renal failure</subject><subject>Tranexamic acid</subject><issn>1476-7058</issn><issn>1476-4954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPwzAQhC0EoqXwE0A5cknxK7F7A1UUkCpxKWdr64calMTFTgT99zhqypGLdzWa8Y4-hG4JnhMs8QPhohS4kHOKKUkPWVBSnKHpoOd8UfDzcR9ME3QV4ydOTo6LSzRhBS4lI3yKVpudzaxzVneZd9k--P3uUIPuKp310Q5aF6C1P9AkBXRlMudDpm2EYKHNYgpWvr1GFw7qaG_GOUMfq-fN8jVfv7-8LZ_WuWZl2eWlKDmGRUG2kgmteVodSGuolsLwBdsKLhkAlYKmos5QyYEZIyghQAVzbIbuj_-mol-9jZ1qqqhtXaeKvo-KlpRyiZmgyVocrTr4GIN1ah-qBsJBEawGhOqEUA0I1Ygw5e7GE_22seYvdWKWDI9HQ9UmFA18-1Ab1cGh9sElVrqKiv1_4xfeB37E</recordid><startdate>20221212</startdate><enddate>20221212</enddate><creator>Binyamin, Yair</creator><creator>Orbach-Zinger, Sharon</creator><creator>Gruzman, Igor</creator><creator>Frenkel, Amit</creator><creator>Lerman, Sofia</creator><creator>Zlotnik, Alexander</creator><creator>Frank, Dmitry</creator><creator>Ioscovich, Alexander</creator><creator>Erez, Offer</creator><creator>Heesen, Michael</creator><general>Taylor &amp; Francis</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2147-7353</orcidid></search><sort><creationdate>20221212</creationdate><title>The effect of prophylactic use of tranexamic acid for cesarean section</title><author>Binyamin, Yair ; Orbach-Zinger, Sharon ; Gruzman, Igor ; Frenkel, Amit ; Lerman, Sofia ; Zlotnik, Alexander ; Frank, Dmitry ; Ioscovich, Alexander ; Erez, Offer ; Heesen, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-67640a951b837cc4a95fa8ed2c87d493b7483aa2872405fd284a3dd7211a273f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>cesarean section</topic><topic>hemoglobin</topic><topic>post-partum hemorrhage</topic><topic>prophylaxis</topic><topic>renal failure</topic><topic>Tranexamic acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Binyamin, Yair</creatorcontrib><creatorcontrib>Orbach-Zinger, Sharon</creatorcontrib><creatorcontrib>Gruzman, Igor</creatorcontrib><creatorcontrib>Frenkel, Amit</creatorcontrib><creatorcontrib>Lerman, Sofia</creatorcontrib><creatorcontrib>Zlotnik, Alexander</creatorcontrib><creatorcontrib>Frank, Dmitry</creatorcontrib><creatorcontrib>Ioscovich, Alexander</creatorcontrib><creatorcontrib>Erez, Offer</creatorcontrib><creatorcontrib>Heesen, Michael</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of maternal-fetal &amp; neonatal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Binyamin, Yair</au><au>Orbach-Zinger, Sharon</au><au>Gruzman, Igor</au><au>Frenkel, Amit</au><au>Lerman, Sofia</au><au>Zlotnik, Alexander</au><au>Frank, Dmitry</au><au>Ioscovich, Alexander</au><au>Erez, Offer</au><au>Heesen, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of prophylactic use of tranexamic acid for cesarean section</atitle><jtitle>The journal of maternal-fetal &amp; neonatal medicine</jtitle><addtitle>J Matern Fetal Neonatal Med</addtitle><date>2022-12-12</date><risdate>2022</risdate><volume>35</volume><issue>25</issue><spage>9157</spage><epage>9162</epage><pages>9157-9162</pages><issn>1476-7058</issn><eissn>1476-4954</eissn><abstract>Treatment with tranexamic acid (TxA) significantly reduces maternal death due to postpartum hemorrhage. There is increasing interest in whether it can also be used as prophylaxis for postpartum hemorrhage, especially during cesarean sections (CS). This impact study is aimed to determine the effect of routine prophylactic tranexamic acid during CS on maternal hemorrhage and the rate of the associated side effects. This retrospective population-based cohort single-center impact study include 2000 women who delivered by CS divided into two groups with (n = 1000) and without (n = 1000) prophylactic administration of 1gram TxA prior to surgery. Primary outcomes were to determine the: (1) rate of women experiencing &gt;10% or ≥2 g/dL hemoglobin drop from the preoperative concentration within 24 h after CS. (2) incidence of women having a hemoglobin drop of ≥2 g/dL. Women who did not receive TxA prophylactic had a higher rate of &gt;10% hemoglobin decrease and a higher rate of ≥2 g/dL hemoglobin decrease Than those who received TxA prophylaxis (p &lt; .0001, for both). Mean hospital stay (p = .002) and umbilical cord pH (p &lt; .05) were higher among those who received TxA prophylaxis than in those who were not treated. The finding of our study suggest that prophylactic administration of TxA prior to CS improves maternal and neonatal outcomes.</abstract><cop>England</cop><pub>Taylor &amp; Francis</pub><pmid>35068314</pmid><doi>10.1080/14767058.2021.2019215</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-2147-7353</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 1476-7058
ispartof The journal of maternal-fetal & neonatal medicine, 2022-12, Vol.35 (25), p.9157-9162
issn 1476-7058
1476-4954
language eng
recordid cdi_pubmed_primary_35068314
source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects cesarean section
hemoglobin
post-partum hemorrhage
prophylaxis
renal failure
Tranexamic acid
title The effect of prophylactic use of tranexamic acid for cesarean section
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T18%3A28%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effect%20of%20prophylactic%20use%20of%20tranexamic%20acid%20for%20cesarean%20section&rft.jtitle=The%20journal%20of%20maternal-fetal%20&%20neonatal%20medicine&rft.au=Binyamin,%20Yair&rft.date=2022-12-12&rft.volume=35&rft.issue=25&rft.spage=9157&rft.epage=9162&rft.pages=9157-9162&rft.issn=1476-7058&rft.eissn=1476-4954&rft_id=info:doi/10.1080/14767058.2021.2019215&rft_dat=%3Cproquest_pubme%3E2622480372%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c366t-67640a951b837cc4a95fa8ed2c87d493b7483aa2872405fd284a3dd7211a273f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2622480372&rft_id=info:pmid/35068314&rfr_iscdi=true