The interaction between free Ca 2+ in host cells and invasion of E. tenella

Eimeria tenella is the most pathogenic and common coccidia that causes chicken coccidiosis. The intracellular free Ca of the host cell is closely related to the invasion, development, and proliferation of intracellular parasites. To determine the dynamic changes of intracellular free Ca and its func...

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Bibliographic Details
Published in:Parasitology research (1987) 2022-03, Vol.121 (3), p.965
Main Authors: Lv, Xiaoling, Chen, Zhaoying, Zheng, Mingxue, Bai, Rui, Zhang, Li, Zhang, Xuesong, Duan, Buting, Zhao, Yongjuan, Yin, Liyang, Fan, Bingling, Cui, Kailing, Xu, Tong
Format: Article
Language:English
Subjects:
Animals
Cecum - parasitology
Chick Embryo
Chickens
Coccidiosis - veterinary
Eimeria tenella - metabolism
Poultry Diseases - parasitology
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Summary:Eimeria tenella is the most pathogenic and common coccidia that causes chicken coccidiosis. The intracellular free Ca of the host cell is closely related to the invasion, development, and proliferation of intracellular parasites. To determine the dynamic changes of intracellular free Ca and its function in the process of E. tenella invading host cells, we established a chick embryo cecal epithelial cells model of E. tenella infection. Chick embryo cecal epithelial cells were treated with different Ca signal inhibitor, respectively, and then infected with E. tenella. The results showed that extracellular Ca , Ca channels on the cell membrane, IP3R ion channels on the endoplasmic reticulum membrane, and RyR ion channels regulated the free Ca in cecal epithelial cells. Through fluorescence labeling and invasion rate detection, we found that the intracellular Ca did not change significantly during the invasion of E. tenella, but its stability was critical to the invasion of parasites.
ISSN:1432-1955
DOI:10.1007/s00436-022-07436-4