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Tumor - Induced Osteomalacia Associated with a Maxillary Tumor in Children: A Case Report and Review of the Literature
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic disorder of hypophosphatemia associated with a tumor-producing fibroblast growth factor 23 (FGF23). The maxillofacial tumor is rarely involved in TIO, especially maxillary TIO in children. We presented a 14-year-old boy with osteomalacia and...
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Published in: | Journal of clinical research in pediatric endocrinology 2022-02 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | Tumor-induced osteomalacia (TIO) is a rare paraneoplastic disorder of hypophosphatemia associated with a tumor-producing fibroblast growth factor 23 (FGF23). The maxillofacial tumor is rarely involved in TIO, especially maxillary TIO in children. We presented a 14-year-old boy with osteomalacia and high serum levels of FGF23, a hormone associated with decreased phosphate resorption due to a maxillary tumor. The patient was treated with oral phosphorus and calcitriol, and received surgical removal of tumor. After 21 months follow-up, he was pain free and had returned to full activity. We reviewed 5 reports of pediatric patients with TIO in oral and maxillofacial region. Tumors localized in mandible (2/5), maxilla (2/5), both mandible and maxilla (1/5). Mean time from onset of signs to diagnosis was 21,9 months. |
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ISSN: | 1308-5735 |