Usual Interstitial Pneumonia Pattern Interstitial Lung Disease Developed in a Patient with IgG4-related Chronic Sclerosing Sialadenitis: A Case Report

A 69-year-old man was diagnosed with immunoglobulin (Ig) G4-related disease (IgG4-RD) at 62 years old. At that time, he had high serum IgG4 levels and bilateral submandibular gland swelling on CT; thus, a gland biopsy was performed. Because a reticular shadow was found on chest CT, a lung surgical b...

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Bibliographic Details
Published in:Internal Medicine 2022, pp.8937-21
Main Authors: Yamamoto, Hiroshi, Komatsu, Masamichi, Sonehara, Kei, Ikuyama, Yuichi, Urushihata, Kazuhisa, Tateishi, Kazunari, Kitaguchi, Yoshiaki, Ushuiki, Atsuhito, Asaka, Shiho, Uehara, Takeshi, Kawakami, Satoshi, Mori, Kentaro, Hamanaka, Kazutoshi, Nishie, Kenichi, Hebisawa, Akira, Hanaoka, Masayuki
Format: Article
Language:English
Subjects:
immunoglobulin (Ig) G4
immunoglobulin (Ig) G4-related disease (IgG4-RD)
interstitial pneumonia
progressive fibrosing
usual interstitial pneumonia (UIP)
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Summary:A 69-year-old man was diagnosed with immunoglobulin (Ig) G4-related disease (IgG4-RD) at 62 years old. At that time, he had high serum IgG4 levels and bilateral submandibular gland swelling on CT; thus, a gland biopsy was performed. Because a reticular shadow was found on chest CT, a lung surgical biopsy was also performed. The specimens revealed usual interstitial pneumonia (UIP) pattern interstitial pneumonia with some IgG4-positive cells. The patient was subsequently followed up without treatment. His forced vital capacity and radiological findings progressively deteriorated, consistent with UIP pattern interstitial lung disease but different from a lung lesion of IgG4-RD.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.8937-21