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Comparison of the diagnostic efficacy of 68 Ga-FAPI-04 PET/MR and 18 F-FDG PET/CT in patients with pancreatic cancer
We sought to assess the performance of Ga-FAPI-04 PET/MR for the diagnosis of primary tumours as well as metastatic lesions in patients with pancreatic cancer and to compare the results with those of F-FDG PET/CT. Prospectively, we evaluated 33 patients suspected to have pancreatic adenocarcinoma,...
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| Published in: | European journal of nuclear medicine and molecular imaging 2022-07, Vol.49 (8), p.2877 |
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| Main Authors: | , , , , , , , , , , |
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| container_issue | 8 |
| container_start_page | 2877 |
| container_title | European journal of nuclear medicine and molecular imaging |
| container_volume | 49 |
| creator | Zhang, Zeyu Jia, Guorong Pan, Guixia Cao, Kai Yang, Qinqin Meng, Hongyu Yang, Jian Zhang, Lu Wang, Tao Cheng, Chao Zuo, Changjing |
| description | We sought to assess the performance of
Ga-FAPI-04 PET/MR for the diagnosis of primary tumours as well as metastatic lesions in patients with pancreatic cancer and to compare the results with those of
F-FDG PET/CT.
Prospectively, we evaluated 33 patients suspected to have pancreatic adenocarcinoma, of whom thirty-two were confirmed by histopathology, and one had autoimmune pancreatitis confirmed by needle biopsy and glucocorticoid treatment. Within 1 week, each patient underwent both
Ga-FAPI-04 PET/MR and
F-FDG PET/CT. Comparisons of the detection abilities for primary tumours, lymph nodes, and metastases were conducted for the two imaging approaches. The original maximum standard uptake values (SUV
) and normalised SUV
(SUV
/SUV
) of paired lesions on
Ga-FAPI-04 PET/MR and
F-FDG PET/CT were measured and compared.
Thirty pancreatic cancer patients and three pancreatitis patients were enrolled.
Ga-FAPI-04 PET/MR and
F-FDG PET/CT exhibited equivalent (100%) detection rates for primary tumours. The original/normalised SUV
of primary tumours on
Ga-FAPI-04 PET was markedly higher than that on
F-FDG (p |
| doi_str_mv | 10.1007/s00259-022-05729-5 |
| format | article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_35243518</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>35243518</sourcerecordid><originalsourceid>FETCH-pubmed_primary_352435183</originalsourceid><addsrcrecordid>eNqFTktOwzAUtJAQLZ8LsEDvAqbPTt3YSxSawgKpQtlXD8ehRsSJbAPqbTgLJ6NFsGY1X42GsUuB1wKxnCVEqQxHKTmqUhqujthULIThJWozYacpvSAKLbU5YZNCyXmhhJ6y92roR4o-DQGGDvLWQevpOQwpewuu67wluztECw1fnyvi9c36nuMc1stm9vAIFFoQGmpe365-vKoBH2Ck7F3ICT583u5VsNHRYdLuqYvn7Lij1-QufvGMXdXLprrj49tT79rNGH1Pcbf5O1r8W_gG9aZLxA</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Comparison of the diagnostic efficacy of 68 Ga-FAPI-04 PET/MR and 18 F-FDG PET/CT in patients with pancreatic cancer</title><source>Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List</source><creator>Zhang, Zeyu ; Jia, Guorong ; Pan, Guixia ; Cao, Kai ; Yang, Qinqin ; Meng, Hongyu ; Yang, Jian ; Zhang, Lu ; Wang, Tao ; Cheng, Chao ; Zuo, Changjing</creator><creatorcontrib>Zhang, Zeyu ; Jia, Guorong ; Pan, Guixia ; Cao, Kai ; Yang, Qinqin ; Meng, Hongyu ; Yang, Jian ; Zhang, Lu ; Wang, Tao ; Cheng, Chao ; Zuo, Changjing</creatorcontrib><description>We sought to assess the performance of
Ga-FAPI-04 PET/MR for the diagnosis of primary tumours as well as metastatic lesions in patients with pancreatic cancer and to compare the results with those of
F-FDG PET/CT.
Prospectively, we evaluated 33 patients suspected to have pancreatic adenocarcinoma, of whom thirty-two were confirmed by histopathology, and one had autoimmune pancreatitis confirmed by needle biopsy and glucocorticoid treatment. Within 1 week, each patient underwent both
Ga-FAPI-04 PET/MR and
F-FDG PET/CT. Comparisons of the detection abilities for primary tumours, lymph nodes, and metastases were conducted for the two imaging approaches. The original maximum standard uptake values (SUV
) and normalised SUV
(SUV
/SUV
) of paired lesions on
Ga-FAPI-04 PET/MR and
F-FDG PET/CT were measured and compared.
Thirty pancreatic cancer patients and three pancreatitis patients were enrolled.
Ga-FAPI-04 PET/MR and
F-FDG PET/CT exhibited equivalent (100%) detection rates for primary tumours. The original/normalised SUV
of primary tumours on
Ga-FAPI-04 PET was markedly higher than that on
F-FDG (p < 0.05). Sixteen pancreatic cancer patients had pancreatic parenchymal uptake, whereas
F-FDG PET images showed parenchymal uptake in only four patients (53.33% vs. 13.33%, p < 0.001).
Ga-FAPI-04 PET detected more positive lymph nodes than
F-FDG PET (42 vs. 30, p < 0.001), while
F-FDG PET was able to detect more liver metastases than
Ga-FAPI-04 (181 vs. 104, p < 0.001). In addition, multisequence MR imaging helped explain ten pancreatic cancers that could not be definitively revealed due to
Ga-FAPI-04 inflammatory uptake and identified more liver metastases than
F-FDG (256 vs. 181, p < 0.001).
Ga-FAPI-04 PET might be better than
F-FDG PET in the detection of suspicious lymph node metastases. MR multiple sequence imaging of
Ga-FAPI-04 PET/MR was helpful for explaining pancreatic lesions in patients with obstructive inflammation and detecting tiny liver metastases.</description><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-022-05729-5</identifier><identifier>PMID: 35243518</identifier><language>eng</language><publisher>Germany</publisher><subject>Adenocarcinoma ; Fluorodeoxyglucose F18 ; Humans ; Liver Neoplasms ; Magnetic Resonance Imaging ; Pancreatic Neoplasms ; Pancreatic Neoplasms - diagnostic imaging ; Positron Emission Tomography Computed Tomography - methods ; Quinolines</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2022-07, Vol.49 (8), p.2877</ispartof><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-2981-5890</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35243518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Zeyu</creatorcontrib><creatorcontrib>Jia, Guorong</creatorcontrib><creatorcontrib>Pan, Guixia</creatorcontrib><creatorcontrib>Cao, Kai</creatorcontrib><creatorcontrib>Yang, Qinqin</creatorcontrib><creatorcontrib>Meng, Hongyu</creatorcontrib><creatorcontrib>Yang, Jian</creatorcontrib><creatorcontrib>Zhang, Lu</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Cheng, Chao</creatorcontrib><creatorcontrib>Zuo, Changjing</creatorcontrib><title>Comparison of the diagnostic efficacy of 68 Ga-FAPI-04 PET/MR and 18 F-FDG PET/CT in patients with pancreatic cancer</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>We sought to assess the performance of
Ga-FAPI-04 PET/MR for the diagnosis of primary tumours as well as metastatic lesions in patients with pancreatic cancer and to compare the results with those of
F-FDG PET/CT.
Prospectively, we evaluated 33 patients suspected to have pancreatic adenocarcinoma, of whom thirty-two were confirmed by histopathology, and one had autoimmune pancreatitis confirmed by needle biopsy and glucocorticoid treatment. Within 1 week, each patient underwent both
Ga-FAPI-04 PET/MR and
F-FDG PET/CT. Comparisons of the detection abilities for primary tumours, lymph nodes, and metastases were conducted for the two imaging approaches. The original maximum standard uptake values (SUV
) and normalised SUV
(SUV
/SUV
) of paired lesions on
Ga-FAPI-04 PET/MR and
F-FDG PET/CT were measured and compared.
Thirty pancreatic cancer patients and three pancreatitis patients were enrolled.
Ga-FAPI-04 PET/MR and
F-FDG PET/CT exhibited equivalent (100%) detection rates for primary tumours. The original/normalised SUV
of primary tumours on
Ga-FAPI-04 PET was markedly higher than that on
F-FDG (p < 0.05). Sixteen pancreatic cancer patients had pancreatic parenchymal uptake, whereas
F-FDG PET images showed parenchymal uptake in only four patients (53.33% vs. 13.33%, p < 0.001).
Ga-FAPI-04 PET detected more positive lymph nodes than
F-FDG PET (42 vs. 30, p < 0.001), while
F-FDG PET was able to detect more liver metastases than
Ga-FAPI-04 (181 vs. 104, p < 0.001). In addition, multisequence MR imaging helped explain ten pancreatic cancers that could not be definitively revealed due to
Ga-FAPI-04 inflammatory uptake and identified more liver metastases than
F-FDG (256 vs. 181, p < 0.001).
Ga-FAPI-04 PET might be better than
F-FDG PET in the detection of suspicious lymph node metastases. MR multiple sequence imaging of
Ga-FAPI-04 PET/MR was helpful for explaining pancreatic lesions in patients with obstructive inflammation and detecting tiny liver metastases.</description><subject>Adenocarcinoma</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Liver Neoplasms</subject><subject>Magnetic Resonance Imaging</subject><subject>Pancreatic Neoplasms</subject><subject>Pancreatic Neoplasms - diagnostic imaging</subject><subject>Positron Emission Tomography Computed Tomography - methods</subject><subject>Quinolines</subject><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFTktOwzAUtJAQLZ8LsEDvAqbPTt3YSxSawgKpQtlXD8ehRsSJbAPqbTgLJ6NFsGY1X42GsUuB1wKxnCVEqQxHKTmqUhqujthULIThJWozYacpvSAKLbU5YZNCyXmhhJ6y92roR4o-DQGGDvLWQevpOQwpewuu67wluztECw1fnyvi9c36nuMc1stm9vAIFFoQGmpe365-vKoBH2Ck7F3ICT583u5VsNHRYdLuqYvn7Lij1-QufvGMXdXLprrj49tT79rNGH1Pcbf5O1r8W_gG9aZLxA</recordid><startdate>202207</startdate><enddate>202207</enddate><creator>Zhang, Zeyu</creator><creator>Jia, Guorong</creator><creator>Pan, Guixia</creator><creator>Cao, Kai</creator><creator>Yang, Qinqin</creator><creator>Meng, Hongyu</creator><creator>Yang, Jian</creator><creator>Zhang, Lu</creator><creator>Wang, Tao</creator><creator>Cheng, Chao</creator><creator>Zuo, Changjing</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0002-2981-5890</orcidid></search><sort><creationdate>202207</creationdate><title>Comparison of the diagnostic efficacy of 68 Ga-FAPI-04 PET/MR and 18 F-FDG PET/CT in patients with pancreatic cancer</title><author>Zhang, Zeyu ; Jia, Guorong ; Pan, Guixia ; Cao, Kai ; Yang, Qinqin ; Meng, Hongyu ; Yang, Jian ; Zhang, Lu ; Wang, Tao ; Cheng, Chao ; Zuo, Changjing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_352435183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenocarcinoma</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Liver Neoplasms</topic><topic>Magnetic Resonance Imaging</topic><topic>Pancreatic Neoplasms</topic><topic>Pancreatic Neoplasms - diagnostic imaging</topic><topic>Positron Emission Tomography Computed Tomography - methods</topic><topic>Quinolines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Zeyu</creatorcontrib><creatorcontrib>Jia, Guorong</creatorcontrib><creatorcontrib>Pan, Guixia</creatorcontrib><creatorcontrib>Cao, Kai</creatorcontrib><creatorcontrib>Yang, Qinqin</creatorcontrib><creatorcontrib>Meng, Hongyu</creatorcontrib><creatorcontrib>Yang, Jian</creatorcontrib><creatorcontrib>Zhang, Lu</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Cheng, Chao</creatorcontrib><creatorcontrib>Zuo, Changjing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Zeyu</au><au>Jia, Guorong</au><au>Pan, Guixia</au><au>Cao, Kai</au><au>Yang, Qinqin</au><au>Meng, Hongyu</au><au>Yang, Jian</au><au>Zhang, Lu</au><au>Wang, Tao</au><au>Cheng, Chao</au><au>Zuo, Changjing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the diagnostic efficacy of 68 Ga-FAPI-04 PET/MR and 18 F-FDG PET/CT in patients with pancreatic cancer</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2022-07</date><risdate>2022</risdate><volume>49</volume><issue>8</issue><spage>2877</spage><pages>2877-</pages><eissn>1619-7089</eissn><abstract>We sought to assess the performance of
Ga-FAPI-04 PET/MR for the diagnosis of primary tumours as well as metastatic lesions in patients with pancreatic cancer and to compare the results with those of
F-FDG PET/CT.
Prospectively, we evaluated 33 patients suspected to have pancreatic adenocarcinoma, of whom thirty-two were confirmed by histopathology, and one had autoimmune pancreatitis confirmed by needle biopsy and glucocorticoid treatment. Within 1 week, each patient underwent both
Ga-FAPI-04 PET/MR and
F-FDG PET/CT. Comparisons of the detection abilities for primary tumours, lymph nodes, and metastases were conducted for the two imaging approaches. The original maximum standard uptake values (SUV
) and normalised SUV
(SUV
/SUV
) of paired lesions on
Ga-FAPI-04 PET/MR and
F-FDG PET/CT were measured and compared.
Thirty pancreatic cancer patients and three pancreatitis patients were enrolled.
Ga-FAPI-04 PET/MR and
F-FDG PET/CT exhibited equivalent (100%) detection rates for primary tumours. The original/normalised SUV
of primary tumours on
Ga-FAPI-04 PET was markedly higher than that on
F-FDG (p < 0.05). Sixteen pancreatic cancer patients had pancreatic parenchymal uptake, whereas
F-FDG PET images showed parenchymal uptake in only four patients (53.33% vs. 13.33%, p < 0.001).
Ga-FAPI-04 PET detected more positive lymph nodes than
F-FDG PET (42 vs. 30, p < 0.001), while
F-FDG PET was able to detect more liver metastases than
Ga-FAPI-04 (181 vs. 104, p < 0.001). In addition, multisequence MR imaging helped explain ten pancreatic cancers that could not be definitively revealed due to
Ga-FAPI-04 inflammatory uptake and identified more liver metastases than
F-FDG (256 vs. 181, p < 0.001).
Ga-FAPI-04 PET might be better than
F-FDG PET in the detection of suspicious lymph node metastases. MR multiple sequence imaging of
Ga-FAPI-04 PET/MR was helpful for explaining pancreatic lesions in patients with obstructive inflammation and detecting tiny liver metastases.</abstract><cop>Germany</cop><pmid>35243518</pmid><doi>10.1007/s00259-022-05729-5</doi><orcidid>https://orcid.org/0000-0002-2981-5890</orcidid></addata></record> |
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| identifier | EISSN: 1619-7089 |
| ispartof | European journal of nuclear medicine and molecular imaging, 2022-07, Vol.49 (8), p.2877 |
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| language | eng |
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| source | Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List |
| subjects | Adenocarcinoma Fluorodeoxyglucose F18 Humans Liver Neoplasms Magnetic Resonance Imaging Pancreatic Neoplasms Pancreatic Neoplasms - diagnostic imaging Positron Emission Tomography Computed Tomography - methods Quinolines |
| title | Comparison of the diagnostic efficacy of 68 Ga-FAPI-04 PET/MR and 18 F-FDG PET/CT in patients with pancreatic cancer |
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