Antifouling activity of terpenoids from the corals Sinularia flexibilis and Muricella sp. against the bryozoan Bugula neritina

Marine natural products are promising sources of green antifoulants. Here, a new compound (1) was isolated from the soft coral Sinularia flexibilis. This compound, another nine cembranoids (2-10) from S. flexibilis, and three eunicellin-type diterpenoids (11-13) from the gorgonian Muricella sp. were...

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Bibliographic Details
Published in:Journal of asian natural products research 2023, Vol.25 (1), p.85-94
Main Authors: Wu, Zhi-Wen, Wang, Zhi-Xuan, Guo, Yuan-Qiang, Tang, Sheng-An, Feng, Dan-Qing
Format: Article
Language:English
Subjects:
Animals
Anthozoa
Antifoulants
Antifouling
Antifouling substances
Antifouling terpenoids
Biofouling - prevention & control
Bryozoa
Bugula neritina
Corals
Diterpenes
Muricella sp
Natural products
Sinularia flexibilis
Structure-Activity Relationship
structure-activity relationship (SAR)
Structure-activity relationships
Terpenes
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Summary:Marine natural products are promising sources of green antifoulants. Here, a new compound (1) was isolated from the soft coral Sinularia flexibilis. This compound, another nine cembranoids (2-10) from S. flexibilis, and three eunicellin-type diterpenoids (11-13) from the gorgonian Muricella sp. were tested for antifouling activity against larval settlement of the bryozoan Bugula neritina. Compounds 2, 3, 4, 9, 12, and 13 exhibited significant antifouling activity, with EC 50 values of 18.2, 99.7, 67.9, 35.6, 33.9, and 49.3 μM, respectively. Analysis of the structure-activity relationships suggested that the hydroxy group at C-13 in compound 4 reduced its antifouling activity.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2022.2046562