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Combination Immunosuppressive Therapy for Giant Cell Myocarditis: A Case Report

A 60-year-old woman with a history of hypothyroidism was referred to our hospital for shortness of breath and a left ventricular ejection fraction (LVEF) of 13%, which required continuous dobutamine injection with intra-aortic balloon pump support. An endomyocardial biopsy obtained from the right ve...

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Bibliographic Details
Published in:Internal Medicine 2022, pp.9112-21
Main Authors: Funaki, Takashi, Saji, Mike, Murai, Tatsuya, Higuchi, Ryosuke, Nanasato, Mamoru, Isobe, Mitsuaki
Format: Article
Language:English
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Summary:A 60-year-old woman with a history of hypothyroidism was referred to our hospital for shortness of breath and a left ventricular ejection fraction (LVEF) of 13%, which required continuous dobutamine injection with intra-aortic balloon pump support. An endomyocardial biopsy obtained from the right ventricle revealed an infiltration of giant cells and eosinophils, indicating giant cell myocarditis. In addition to heart failure treatment, combined immunotherapy with steroids, tacrolimus, and intravenous immunoglobulin was administered. Transthoracic echocardiography demonstrated a dramatic improvement in the LVEF after this therapy, and the patient was discharged home without symptoms on day 72.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.9112-21