Preparation and preliminary evaluation study of [131I]iodocolchicine-gallic-AuNPs: a potential scintigraphic agent for inflammation detection

• Published in: International journal of radiation biology 2022-08, Vol.98 (8), p.1358-1365
• Main Authors: Essa, Basma M., Selim, Adli A., El-Kawy, O. A., Abdelaziz, Gamal
• Format: Article
• Language: English
• Subjects: colchicine; Gallic-AuNPs; I-radiolabeling; inflammation; scintigraphy
• ISSN: 0955-3002; 1362-3095
• DOI: 10.1080/09553002.2022.2047824

Nanomedicine offers great potential for scintigraphic diagnostic imaging with lower risk and higher quality compared to other traditional techniques. This work aimed to develop and evaluate gold nanoparticles combined with gallic acid (gallic-AuNPs) and [ 131 I]iodocolchicine as a scintigraphic probe for inflammation. [ 131 I]iodocolchicine-gallic-AuNPs were synthesized via chemical reduction method where gallic acid was used as reducing agent and [ 131 I]iodocolchicine was used as stabilizing agent. Then a characteristic profile for the synthesized nano-platform was performed including size analysis, zeta potential, radiochemical yield and in-vivo biodistribution in inflammation bearing mice. This platform was successfully synthesized with good stability, appropriate particle size (10 nm diameter for AuNPs), and high radiochemical purity for [ 131 I]iodocolchicine (96.79%). The in-vivo study indicated that [ 131 I]iodocolchicine-gallic-AuNPs accumulated with a high target to non-target ratio in intravenous injection and high retention value in intra-inflammation injection in inflammation model. The obtained data supported the usefulness of the new platform ([ 131 I]iodocolchicine-gallic-AuNPs) as a tracer for the detection and localization of inflammation.