Concurrent pigeon paramyxovirus-1 and Acinetobacter baumannii infection in a fatal case of pneumonia

Pigeon paramyxovirus type 1 (PPMV-1), an antigenic variant of avian paramyxovirus type 1 (APMV-1), mainly infects pigeons. PPMV-1 genotype VI is the dominant genotype infecting pigeons in China. Human infection of avian paramyxovirus was rarely reported, and usually developed mild symptoms, such as...

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Published in:Emerging microbes & infections 2022-12, Vol.11 (1), p.968-977
Main Authors: Zou, Xiaohui, Suo, Lijun, Wang, Yimin, Cao, Hongyun, Mu, Shengrui, Wu, Chao, Yan, Lizhen, Qi, Xiaowei, Lu, Jianwei, Lu, Binghuai, Fan, Yanyan, Li, Hui, Huang, Lixue, Ren, Lili, Liu, Bo, Cao, Bin
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Animals
Birds
clinical metagenomics
Columbidae
cross-species transmission
Genotype & phenotype
Humans
Infections
Male
Newcastle disease virus - genetics
Newcastle diseases virus
Phylogeny
pigeon paramyxovirus type 1
Pneumonia
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Summary:Pigeon paramyxovirus type 1 (PPMV-1), an antigenic variant of avian paramyxovirus type 1 (APMV-1), mainly infects pigeons. PPMV-1 genotype VI is the dominant genotype infecting pigeons in China. Human infection of avian paramyxovirus was rarely reported, and usually developed mild symptoms, such as conjunctivitis. We detected PPMV-1 in the lower respiratory sample from a fatal case with severe pneumonia; this patient aged 64 years presented cough, fever, and haemoptysis for 8 days and was admitted to hospital on Dec 26, 2020. He developed acute respiratory distress syndrome and sepsis in the following days and died of multiple organ failure on Jan 7, 2021. Sputum and blood culture reported multidrug-resistant Acinetobacter baumannii (ABA) for samples collected on days 22 and 19 post-illness, respectively. However, clinical metagenomic sequencing further reported PPMV-1 besides ABA in the bronchoalveolar lavage fluid. The PPMV-1 genome showed 99.21% identity with a Chinese strain and belonged to VI genotype by BLAST analysis. Multiple basic amino acids were observed at the cleavage site of F protein (113RKKRF117), which indicated high virulence of this PPMV-1 strain to poultry. The patient had close contact with pigeons before his illness, and PPMV-1 nucleic acid was detected from the pigeon feather. PPMV antibody was also detected in the patient serum 20 days after illness. In conclusion, concurrent PPMV-1 genotype VI.2.1.1.2.2 and ABA infection were identified in a fatal pneumonia case, and cross-species transmission of PPMV-1 may occur between infected pigeons and the human being.
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2022.2054366