Beneficial effects of fish and fish peptides on main metabolic syndrome associated risk factors: Diabetes, obesity and lipemia

The definition of metabolic syndrome (MetS) fairly varies from one to another guideline and health organization. Per description of world health organization, occurrence of hyperinsulinemia or hyperglycemia in addition to two or more factors of dyslipidemia, hypoalphalipoproteinemia, hypertension an...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2023-10, Vol.63 (26), p.7896-7944
Main Authors: Abachi, Soheila, Pilon, Geneviève, Marette, André, Bazinet, Laurent, Beaulieu, Lucie
Format: Article
Language:English
Subjects:
Biological activity
cardiovascular diseases
Diabetes
Diabetes mellitus
Dyslipidemia
Fish
fish peptides
Hypercholesterolemia
Hyperglycemia
Hyperinsulinemia
Hypertension
Hypoalphalipoproteinemia
Marine fish
Metabolic disorders
Metabolic syndrome
Obesity
Oligopeptides
Peptides
Protein purification
Risk factors
Side effects
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Summary:The definition of metabolic syndrome (MetS) fairly varies from one to another guideline and health organization. Per description of world health organization, occurrence of hyperinsulinemia or hyperglycemia in addition to two or more factors of dyslipidemia, hypoalphalipoproteinemia, hypertension and or large waist circumference factors would be defined as MetS. Conventional therapies and drugs, commonly with adverse effects, are used to treat these conditions and diseases. Nonetheless, in the recent decades scientific community has focused on the discovery of natural compounds to diminish the side effects of these medications. Among many available bioactives, biologically active peptides have notable beneficial effects on the management of diabetes, obesity, hypercholesterolemia, and hypertension. Marine inclusive of fish peptides have exerted significant bioactivities in different experimental in-vitro, in-vivo and clinical settings. This review exclusively focuses on studies from the recent decade investigating hypoglycemic, hypolipidemic, hypercholesterolemic and anti-obesogenic fish and fish peptides. Related extraction, isolation, and purification methodologies of anti-MetS fish biopeptides are reviewed herein for comparison purposes only. Moreover, performance of biopeptides in simulated gastrointestinal environment and structure-activity relationship along with absorption, distribution, metabolism, and excretion properties of selected oligopeptides have been discussed, in brief, to broaden the knowledge of readers on the design and discovery trends of anti-MetS compounds. Supplemental data for this article is available online at https://doi.org/10.1080/10408398.2022.2052261 .
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2022.2052261