Co 3 O 4 Nanoparticles Uniformly Dispersed in Rational Porous Carbon Nano-Boxes for Significantly Enhanced Electrocatalytic Detection of H 2 O 2 Released from Living Cells

A facile and ingenious method to chemical etching-coordinating a metal-organic framework (MOF) followed by an annealing treatment was proposed to prepare Co O nanoparticles uniformly dispersed in rational porous carbon nano-boxes (Co O @CNBs), which was further used to detect H O released from livin...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2022-03, Vol.23 (7)
Main Authors: Xiong, Lulu, Zhang, Yuanyuan, Wu, Shiming, Chen, Feng, Lei, Lingli, Yu, Ling, Li, Changming
Format: Article
Language:English
Subjects:
Biosensing Techniques - methods
Carbon
Cobalt
Electrochemical Techniques - methods
Hydrogen Peroxide
Metal Nanoparticles
Oxides
Porosity
Reproducibility of Results
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A facile and ingenious method to chemical etching-coordinating a metal-organic framework (MOF) followed by an annealing treatment was proposed to prepare Co O nanoparticles uniformly dispersed in rational porous carbon nano-boxes (Co O @CNBs), which was further used to detect H O released from living cells. The Co O @CNBs H O sensor delivers much higher sensitivity than non-etching/coordinating Co O , offering a limit of detection of 2.32 nM. The wide working range covers 10 nM-359 μM H O , while possessing good selectivity and excellent reproducibility. Moreover, this biosensor was used to successfully real-time detect H O released from living cells, including both healthy and tumor cells. The excellent performance holds great promise for Co O @CNBs's applications in electrochemical biomimetic sensing, particularly real-time monitor H O released from living cells.
ISSN:1422-0067